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Titolo:
INTESTINAL NEMATODE PARASITES, CYTOKINES AND EFFECTOR MECHANISMS
Autore:
ELSE KJ; FINKELMAN FD;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,3-239 STOPFORD BLDG,OXFORD RD MANCHESTERM13 9PT LANCS ENGLAND UNIV CINCINNATI,COLL MED,DEPT MED,DIV IMMUNOL CINCINNATI OH 45267
Titolo Testata:
International journal for parasitology
fascicolo: 8, volume: 28, anno: 1998,
pagine: 1145 - 1158
SICI:
0020-7519(1998)28:8<1145:INPCAE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRICHINELLA-SPIRALIS INFECTION; HOST PROTECTIVE IMMUNITY; CD4+ T-CELLS; NIPPOSTRONGYLUS-BRASILIENSIS; TRICHURIS-MURIS; C-KIT; NEMATOSPIROIDES-DUBIUS; RAPID EXPULSION; GASTROINTESTINAL NEMATODES; HELIGMOSOMOIDES-POLYGYRUS;
Keywords:
INTESTINAL NEMATODE PARASITES; TH1; TH2; CYTOKINES; EFFECTOR MECHANISMS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
104
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Else e F.D. Finkelman, "INTESTINAL NEMATODE PARASITES, CYTOKINES AND EFFECTOR MECHANISMS", International journal for parasitology, 28(8), 1998, pp. 1145-1158

Abstract

Laboratory models of intestinal nematode infection have played an important role in developing our understanding of the immune mechanisms that operate against infectious agents. The type of helper T cell response that develops following infection with intestinal nematode parasites is critical to the outcome of infection. The early events that mediate polarisation of the helper T cell subsets towards either Th1 or Th2 during intestinal nematode infection are not well characterised, butit is likely that multiple factors influence the induction of a Th1 or Th2 type response, just as multiple effector mechanisms are involvedin worm expulsion. Costimulatory molecules have been shown to be important in driving T helper cell development down a specific pathway as has the immediate cytokine environment during T cell activation. If helper T cells of the Th2 type gain ascendancy then a protective immune response ensues, mediated by Th2 type cytokines and the effector mechanisms they control. In contrast, if an inappropriate Th1 type responsepredominates the ability to expel infection is compromised. Equally important is the observation that multiple potential effector mechanisms are stimulated by nematode infection, with a unique combination operating against the parasite depending on nematode species and its life cycle stage. Despite the close association between intestinal nematodeinfection and the generation of eosinophilia, mastocytosis and IgE ithas been difficult to consistently demonstrate a role for these effector cells/molecules in resistance to nematode parasites, although mastcells are clearly important in Some cases. It therefore seems that, in general, less classical Th2 controlled effector mechanisms, which remain poorly defined, are probably important in resistance to nematode parasites. Thus, our understanding of both the induction and effector phases remains incomplete and will remain an intense area of interest in the coming years. (C) 1998 Australian Society for Parasitology. Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:53:22