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Titolo:
LACK OF ACTIVE LUNG ANAPHYLAXIS IN CONGENITALLY MAST CELL-DEFICIENT WS WS RATS SENSITIZED WITH THE NEMATODE NIPPOSTRONGYLUS-BRASILIENSIS/
Autore:
NISHIDA M; UCHIKAWA R; TEGOSHI T; YAMADA M; MATSUDA S; SASABE M; ARIZONO N;
Indirizzi:
KYOTO PREFECTURAL UNIV MED,DEPT MED ZOOL KYOTO 6020841 JAPAN KYOTO PREFECTURAL UNIV MED,DEPT MED ZOOL KYOTO 6020841 JAPAN
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 7, volume: 106, anno: 1998,
pagine: 709 - 716
SICI:
0903-4641(1998)106:7<709:LOALAI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE DOMAIN; C-KIT; SYSTEMIC-ANAPHYLAXIS; SMALL DELETION; WBB6F1 MOUSE; IGE; INFECTION; RESPONSES; MICE; PERMEABILITY;
Keywords:
WS/WS RATS; LUNG; MAST CELL; EOSINOPHIL; ANAPHYLAXIS; VASCULAR PERMEABILITY; LTC4; NIPPOSTRONGYLUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Nishida et al., "LACK OF ACTIVE LUNG ANAPHYLAXIS IN CONGENITALLY MAST CELL-DEFICIENT WS WS RATS SENSITIZED WITH THE NEMATODE NIPPOSTRONGYLUS-BRASILIENSIS/", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 106(7), 1998, pp. 709-716

Abstract

Ws/Ws rats are deficient in both mucosal- and connective tissue-type mast cells. To study the role of mast cells in active anaphylaxis, changes in Vascular permeability in the trachea upon intravenous antigen challenge with Evans blue dye were examined in Ws/Ws, heterogenic Ws/+, and normal +/+ rats sensitized with the nematode Nippostrongylus brasiliensis. Antigen challenge resulted in fatal anaphylactic shock in some +/+ and Ws/+ rats, but not in Ws/Ws rats. Marked dye leakage developed within 30 min in the trachea of +/+ and Ws/+ rats, while I Ws/Ws rats showed no substantial increases in the levels of vascular permeability. Ex vivo stimulation of sensitized lung fragments from +/+ animals with specific antigen induced significant releases of histamine andleukotriene (LT) C4, while sensitized Ws/Ws rat-lung fragments did not. In Ws/Ws rats, levels of nematode-specific IgE, IgG1 and IgG2a antibodies as well as levels of lung eosinophilia were not significantly different from those in +/+ rats. These results show that mast cell-deficient Ws/Ws rats fail to develop active anaphylaxis, and this is mediated probably by the lack of mast cell-derived mediators required for initiation of the reaction.

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Documento generato il 27/01/21 alle ore 02:55:53