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Titolo:
STUDY OF MORPHINE HYDROCHLORIDE PERCOLATION-THRESHOLD IN EUDRAGIT(R) RS-PM MATRICES
Autore:
MELGOZA LM; CARABALLO I; ALVAREZFUENTES J; MILLAN M; RABASCO AM;
Indirizzi:
UNIV SEVILLA,FAC FARM,DEPT FARM & TECNOL FARMACEUT,CATEDRA FARM GELEN,C PROF GARCIA GONZALEZ S-N E-41012 SEVILLE SPAIN UNIV SEVILLA,FAC FARM,DEPT FARM & TECNOL FARMACEUT,CATEDRA FARM GELENE-41012 SEVILLE SPAIN
Titolo Testata:
International journal of pharmaceutics
fascicolo: 2, volume: 170, anno: 1998,
pagine: 169 - 177
SICI:
0378-5173(1998)170:2<169:SOMHPI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELEASE; SYSTEMS; SULFATE;
Keywords:
MORPHINE HYDROCHLORIDE; EUDRAGIT((R)) RS-PM; PERCOLATION THRESHOLD; PERCOLATION THEORY; INERT MATRIX; CONTROLLED RELEASE; SOLID DOSAGE FORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Melgoza et al., "STUDY OF MORPHINE HYDROCHLORIDE PERCOLATION-THRESHOLD IN EUDRAGIT(R) RS-PM MATRICES", International journal of pharmaceutics, 170(2), 1998, pp. 169-177

Abstract

Percolation theory has been applied in the pharmaceutical field since1987. The knowledge of the percolation thresholds of a system resultsin a clear improvement of the design of controlled release dosage forms such as inert matrices. In the present paper, the percolation thresholds of morphine hydrochloride inert matrices have been estimated andthe obtained results have been applied to the design of controlled release inert matrices of this drug. The tablets were prepared by compression of binary mixtures of morphine hydrochloride, as a drug of clinical interest to cancer patients, and Eudragit(R) RS-PM, a hydrophobic acrylic polymer as matrix forming material. Drug loadings between 10% and 90% (w/w) were prepared, keeping constant the drug and excipient particle sizes. The dissolution assay was carried out exposing only oneside of the tablets to the dissolution medium. The drug percolation threshold was estimated following the method of Leuenberger and Bonny as 0.506 +/- 0.014 of total porosity, corresponding to ca. 40% (w/w) drug content. The scanning electron microscopy (SEM) micrographs corresponding to the tablet side facing the lower punch and to the cross-section of these matrices are in agreement with the estimated percolation range. On the other hand, according to the SEM study and to the tabletintegrity after the release assays, the excipient percolation threshold is expected to range from 65 to 80% (w/w) of drug, i.e. from 29.5 to 17% (v/v) of excipient. The release profiles of the matrices situated above the percolation threshold of the swelling substances (more than 41% v/v of excipient) have shown practically linear release profiles, which appear to not be sensitive to the drug load. (C) 1998 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:11:02