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Titolo:
DIFFERENTIAL-EFFECTS OF MIGRAINE DRUGS ON CEREBRAL BLOOD-FLOW AUTOREGULATION
Autore:
VRAAMARK T; WALDEMAR G; PAULSON OB;
Indirizzi:
COPENHAGEN UNIV HOSP,RIGSHOSP,CTR NEUROSCI,NEUROBIOL RES UNIT N9201,9BLEGDAMSVEJ DK-2100 COPENHAGEN DENMARK RIGSHOSP,CTR NEUROSCI DK-2100 COPENHAGEN DENMARK
Titolo Testata:
Cephalalgia
fascicolo: 6, volume: 18, anno: 1998,
pagine: 306 - 312
SICI:
0333-1024(1998)18:6<306:DOMDOC>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTORS MEDIATING CONTRACTION; 5-HT1-LIKE RECEPTOR; 5-HT RECEPTORS; SUMATRIPTAN; ERGOTAMINE; ARTERIES; VELOCITY; ATTACKS; DIHYDROERGOTAMINE; ANGIOTENSIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Vraamark et al., "DIFFERENTIAL-EFFECTS OF MIGRAINE DRUGS ON CEREBRAL BLOOD-FLOW AUTOREGULATION", Cephalalgia, 18(6), 1998, pp. 306-312

Abstract

The effect of the migraine drugs ergotamine and sumatriptan on the cerebral blood flow (CBF) autoregulation was studied in halothane/nitrous oxide-anesthetized normotensive Wistar Kyoto rats. Ergotamine, an ergot alkaloid affecting 5HT, norepinephrine, and dopamine receptors, was administered intravenously as a single dose of 25 mu g/kg. Sumatriptan, a selective 5HT(1)-like receptor agonist, was administered by intravenous infusion of 300 mu g/kg/h. CBF was measured with the intracarotid Xe-133-injection method. The blood pressure limits of CBF autoregulation were determined by computerized least sum of square analysis. CBF autoregulation was preserved after both ergotamine and sumatriptan. Ergotamine shifted the lower blood pressure limit of CBF autoregulation towards higher blood pressures from 60+/-3 mmHg to 82+/-4 mmHg (p<0.01), but did not significantly affect the upper blood pressure limit of CBF autoregulation. Sumatriptan had no significant effects on the blood pressure limits of CBF autoregulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:42:13