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Titolo:
ETHANOL-REINFORCED BEHAVIOR IN THE RAT - EFFECTS OF UNCOMPETITIVE NMDA RECEPTOR ANTAGONIST, MEMANTINE
Autore:
PIASECKI J; KOROS E; DYR W; KOSTOWSKI W; DANYSZ W; BIENKOWSKI P;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND WARSAW MED UNIV,DEPT EXPT & CLIN PHARMACOL PL-00927 WARSAW POLAND MERZ & CO,DEPT PHARMACOL RES D-60048 FRANKFURT GERMANY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 354, anno: 1998,
pagine: 135 - 143
SICI:
0014-2999(1998)354:2-3<135:EBITR->2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; GATED ION CHANNELS; PLACE PREFERENCE; MK-801 BLOCKS; COCAINE; EXTINCTION; ALCOHOL; AMPHETAMINE; EXPRESSION; INITIATION;
Keywords:
ETHANOL DRINKING; ETHANOL SELF-ADMINISTRATION EXTINCTION; NMDA RECEPTOR; MEMANTINE; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
J. Piasecki et al., "ETHANOL-REINFORCED BEHAVIOR IN THE RAT - EFFECTS OF UNCOMPETITIVE NMDA RECEPTOR ANTAGONIST, MEMANTINE", European journal of pharmacology, 354(2-3), 1998, pp. 135-143

Abstract

Ethanol has been reported to alter NMDA receptor-mediated biochemicaland electrophysiological responses in vitro. The aim of the present study was to evaluate the effects of an uncompetitive NMDA receptor antagonist memantine, in animal models of alcoholism. Male Wistar rats were trained to drink 8% ethanol in a free-choice, limited access procedure. A separate group of animals was trained to lever press for 8% ethanol in an operant procedure where ethanol was introduced in the presence of sucrose. The selectivity of memantine's actions was assessed bystudying its effects on food or water consumption in separate controlexperiments. Memantine (4.5-24 mg/kg) significantly, but not dose dependently; affected ethanol drinking in the limited access procedure. However, only 6 mg/kg memantine selectively decreased ethanol drinking. Memantine did not alter ethanol intake in rats trained to lever pressfor ethanol in the operant procedure. Only 9 mg/kg memantine reduced operant responding in the extinction procedure in the rats trained to lever press for ethanol. The same dose of memantine significantly reduced the operant behaviour of rats trained to respond for water. These results indicate that: (i) single doses of memantine only moderately and not dose dependently reduce alcohol drinking in the limited access procedure; (ii) memantine produces non-selective effects on operant behaviour in rats trained to lever press for ethanol in an oral self-administration procedure. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:35:16