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Titolo:
BETA-CAROTENE REDUCES THE DUCTULAR (OVAL) CELL REACTION IN THE LIVER OF WISTAR RATS SUBMITTED TO THE RESISTANT HEPATOCYTE MODEL OF CARCINOGENESIS
Autore:
DAGLI MLZ; GUERRA JL; SINHORINI IL; WU TS; RIZZI MBSL; PENTEADO MVC; MORENO FS;
Indirizzi:
UNIV SAO PAULO,FAC VET MED & ZOOTECHNY,DEPT PATHOL,EXPT ONCOL LAB BR-05508900 SAO PAULO BRAZIL UNIV SAO PAULO,FAC PHARMACEUT SCI,DEPT FOOD & EXPT NUTR,LAB DIET NUTR& CANC BR-05508900 SAO PAULO BRAZIL
Titolo Testata:
Pathology
fascicolo: 3, volume: 30, anno: 1998,
pagine: 259 - 266
SICI:
0031-3025(1998)30:3<259:BRTD(C>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAT-STORING CELLS; CHEMICALLY-INDUCED HEPATOCARCINOGENESIS; PERISINUSOIDAL STELLATE CELLS; HEPATOCELLULAR-CARCINOMA; GROWTH-FACTOR; ITO CELLS; VITAMIN-A; PRENEOPLASTIC LESIONS; EXPRESSION; FIBROSIS;
Keywords:
BETA-CAROTENE; VITAMIN-A; DUCTULAR CELL REACTION; OVAL CELLS; HEPATOCARCINOGENESIS; ITO CELLS; MYOFIBROBLASTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
M.L.Z. Dagli et al., "BETA-CAROTENE REDUCES THE DUCTULAR (OVAL) CELL REACTION IN THE LIVER OF WISTAR RATS SUBMITTED TO THE RESISTANT HEPATOCYTE MODEL OF CARCINOGENESIS", Pathology, 30(3), 1998, pp. 259-266

Abstract

The morphology of livers of Wistar rats treated with betacarotene (BC), vitamin A (VA, retinol acetate) or corn oil (CO, controls) and submitted to the resistant hepatocyte model of carcinogenesis was studied. Preneoplastic lesions (PNL) were smaller and less numerous in the BC group. The latter group also presented fewer placental glutathione-S-transferase (GST-P) positive and hematoxylin and eosin (H&E) distinguishable PNL, with smaller mean areas and smaller mean areas of the liveroccupied by PNL. Clear cell foci predominated in BC livers. In picrosirius-stained liver sections, fibrosis, whether or not accompanying the bile ductular cells, surrounded only 16.67% of PNL in the BC group, as compared to 35.71% in the VA group and 87.72% in the CO group. Moreover, the ductular cell reaction was smaller in the BC group. Smooth muscle actin-positive cells surrounded some PNL, mostly in CO rats, andless frequently in the VA and BC groups. Examination by transmission electron microscopy (TEM) showed that cells with nuclei similar to those of perisinusoidal cells, devoid of cytoplasmic fat globules, probably represented myofibroblasts derived from Ito cells and accompanied the ductular cell reaction. On the basis of these results, we suggest that BC reduced not only the PNL but also the ductular (oval) cell reaction in this experimental model.

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Documento generato il 25/05/20 alle ore 01:41:06