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Titolo:
TYPICAL AND ATYPICAL ANTIPSYCHOTICS IN ADOLESCENT SCHIZOPHRENIA - EFFICACY, TOLERABILITY, AND DIFFERENTIAL SENSITIVITY TO EXTRAPYRAMIDAL SYMPTOMS
Autore:
LEWIS R;
Indirizzi:
SUNNYBROOK HLTH SCI CTR,DEPT PSYCHIAT,2075 BAYVIEW AVE TORONTO ON M4N3M5 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON CANADA
Titolo Testata:
Canadian journal of psychiatry
fascicolo: 6, volume: 43, anno: 1998,
pagine: 596 - 604
SICI:
0706-7437(1998)43:6<596:TAAAIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; LIVING HUMAN-BRAIN; D2-DOPAMINE RECEPTOR OCCUPANCY; DOUBLE-BLIND; OPEN TRIAL; TARDIVE-DYSKINESIA; DOPAMINE-RECEPTORS; NEGATIVE SYMPTOMS; OLANZAPINE TRIAL; CLOZAPINE;
Keywords:
ANTIPSYCHOTICS; NEUROLEPTICS; ADOLESCENTS; EFFICACY; TOLERABILITY; EXTRAPYRAMIDAL SYMPTOMS; PET; D-2 RECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
R. Lewis, "TYPICAL AND ATYPICAL ANTIPSYCHOTICS IN ADOLESCENT SCHIZOPHRENIA - EFFICACY, TOLERABILITY, AND DIFFERENTIAL SENSITIVITY TO EXTRAPYRAMIDAL SYMPTOMS", Canadian journal of psychiatry, 43(6), 1998, pp. 596-604

Abstract

Objective: To review the existing literature on the efficacy and tolerability of antipsychotics for adolescent psychosis. The review focuses in particular on literature regarding adverse effects that are thought to have an increased incidence in young patients and on the possible neurobiological bases for such differential sensitivity. Method: Pertinent studies were sought using Medline searches, supplemented by selected bibliographies, and reviewed. Results: There is a relative paucity of research in this area,. in particular, well-controlled trials are lacking. The existing literature suggests fairly good efficacy of both typical and atypical antipsychotics in the treatment of psychotic disorders in children and adolescents. However, the incidence of certain side effects, particularly extrapyramidal symptoms (EPS), is found to be higher in young patients compared with adults. Positron emission tomography (PET) receptor studies in adults have demonstrated that theincidence of EPS is related to dose-dependent dopamine type-2 (D-2) receptor occupancy and that there is a significant relationship betweenthe number of these receptors and age. Conclusions: Improved tolerability is leading to the increasing use of atypical antipsychotics for adolescent patients, though these new drugs do have specific adverse effects of their or-on. There is a need for more controlled studies of atypical antipsychotics in children and adolescents. In particular, dose-finding studies are needed to determine the optimal dose range to produce the greatest improvement with the least side effects for each ofthese new drugs.

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Documento generato il 25/01/20 alle ore 18:26:40