Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMPORTANCE OF INTERLEUKIN-10 IN GENETIC SUSCEPTIBILITY OF MICE TO COCCIDIOIDES-IMMITIS
Autore:
FIERER J; WALLS L; ECKMANN L; YAMAMOTO T; KIRKLAND TN;
Indirizzi:
VA SAN DIEGO HEALTHCARE SYST,INFECT DIS SECT 111F,MED SERV,3350 LA JOLLA VILLAGE DR SAN DIEGO CA 92161 VA SAN DIEGO HEALTHCARE SYST,PATHOL SERV SAN DIEGO CA 00000 VA SAN DIEGO HEALTHCARE SYST,RES SERV SAN DIEGO CA 00000 UNIV CALIF SAN DIEGO,DEPT MED SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,DEPT PATHOL SAN DIEGO CA 92103
Titolo Testata:
Infection and immunity
fascicolo: 9, volume: 66, anno: 1998,
pagine: 4397 - 4402
SICI:
0019-9567(1998)66:9<4397:IOIIGS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL SUBSETS; INTERFERON-GAMMA; CUTANEOUS LEISHMANIASIS; MURINE LEISHMANIASIS; CYTOKINE RESPONSES; IFN-GAMMA; KALA-AZAR; IL-4 GENE; EXPRESSION; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J. Fierer et al., "IMPORTANCE OF INTERLEUKIN-10 IN GENETIC SUSCEPTIBILITY OF MICE TO COCCIDIOIDES-IMMITIS", Infection and immunity, 66(9), 1998, pp. 4397-4402

Abstract

Inbred strains of mice vary in their susceptibility to Coccidioides immiis, We infected resistant DBA/2 (D2) mice and three susceptible strains of mice (C57BL/6 [B6], BALB/c, and CAST/Ei) by intraperitoneal injection of arthroconidia and determined the severity of infection based on colony counts of fungus in the spleens and lungs 14 days after infection, We used quantitative reverse transcription-PCR to measure theamounts of cytokines made in the spleens and lungs of infected mice. Susceptible mice made 1,000-fold more interleukin-10 (IL-10) than resistant D2 mice and about 10-fold more IL-4. In contrast, D2 mice had more IL-12 p40 in their lungs than did B6 mice. Resistant and susceptible mice made equivalent amounts of gamma interferon, IL-6, and IL-2, Inorder to determine whether IL-10 adversely affected the response to C. immitis, we infected IL-10-deficient mice, and they were found to beas resistant as D2 mice. This result indicates that IL-10 plays a crucial role in determining susceptibility to C, immitis in inbred mice, Because IL-4 mRNA levels were higher in most strains of susceptible mice, we also infected IL-4-deficient B6 mice, They were more resistant than B6 controls but not as resistant as IL-10-deficient mice, Thus, both IL-10 and IL-4 adversely affect the ability of C57BL mice to resist infection with C. immitis, but IL-10 has a larger effect and is the cytokine that is consistently associated with susceptibility in all strains of inbred mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/12/18 alle ore 23:17:24