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Titolo:
CHEMOTACTIC ACTIVITY AND IL-8 LEVELS IN THE CEREBROSPINAL-FLUID IN CANINE STEROID-RESPONSIVE MENINGITIS-ARTERIITIS
Autore:
BURGENER I; VANHAM L; JAGGY A; VANDEVELDE M; TIPOLD A;
Indirizzi:
UNIV BERN,INST VET VIROL,LANGGASSSTR 122 CH-3012 BERN SWITZERLAND UNIV BERN,INST VET VIROL CH-3012 BERN SWITZERLAND UNIV BERN,INST ANIM NEUROL CH-3012 BERN SWITZERLAND STATE UNIV GHENT,DEPT SMALL ANIM MED B-9000 GHENT BELGIUM
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 89, anno: 1998,
pagine: 182 - 190
SICI:
0165-5728(1998)89:1-2<182:CAAILI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROTIZING VASCULITIS; ASEPTIC-MENINGITIS; KAWASAKI-DISEASE; HUMAN NEUTROPHIL; PAIN SYNDROME; INTERLEUKIN-8; DOGS; MIGRATION; ARTERITIS; INFLAMMATION;
Keywords:
STEROID RESPONSIVE MENINGITIS-ARTERIITIS (SRMA); INTERLEUKIN-8 (IL-8); CEREBROSPINAL FLUID (CSF); GLUCOCORTICOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
I. Burgener et al., "CHEMOTACTIC ACTIVITY AND IL-8 LEVELS IN THE CEREBROSPINAL-FLUID IN CANINE STEROID-RESPONSIVE MENINGITIS-ARTERIITIS", Journal of neuroimmunology, 89(1-2), 1998, pp. 182-190

Abstract

Steroid responsive meningitis-arteriitis (SRMA) is a systemic immune disorder, characterized by inflammatory-stenosing lesions of the meningeal arteries and meningitis. The predilection of the disease for the central nervous system (CNS) remains unexplained. In this study, chemotactic activity and chemotactic factors were measured in the cerebrospinal fluid (CSF) of dogs with SRMA. CSF of dogs with SRMA exerted a marked chemotactic activity for leukocytes. Neutrophils were attracted to a similar degree as by CSF from animals with bacterial encephalitis. Chemotactic activity was also noted for mononuclear cells, however, by far weaker than in CSF from animals with viral encephalitis. While the inflammatory process could be suppressed with glucocorticoid treatment, the chemotactic activity of CSF persisted. We could identify IL-8-like activities using a desensitization assay in the CSF of animals with SRMA and also found increased IgA levels. Increased chemotactic activity for polymorphonuclear leukocytes correlated positively with thelevels of IL-8-like activity in CSF. Our observations clearly suggestthat in SRMA chemotactic factors are generated in the CNS. These include IL-8, but probably also others. The intensity of this production appears to correlate with IgA levels in the CSF suggesting either a causal link or reflecting the severity of the inflammation. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:57:27