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Titolo:
CONCENTRATION-DEPENDENT EFFECTS OF PENTOXIFYLLINE ON MIGRATION AND MYELIN PHAGOCYTOSIS BY MACROPHAGES
Autore:
LIEFNER M; MARUSCHAK B; BRUCK W;
Indirizzi:
GEORG AUGUST UNIV,INST NEUROPATHOL,DEPT NEUROPATHOL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY GEORG AUGUST UNIV,INST NEUROPATHOL,DEPT NEUROPATHOL D-37075 GOTTINGENGERMANY
Titolo Testata:
Journal of neuroimmunology
fascicolo: 1-2, volume: 89, anno: 1998,
pagine: 97 - 103
SICI:
0165-5728(1998)89:1-2<97:CEOPOM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; TUMOR-NECROSIS-FACTOR; PERIPHERAL NERVOUS-SYSTEM; IMMUNE-MEDIATED DEMYELINATION; WALLERIAN DEGENERATION; LEWIS RATS; C57BL/OLA MICE; REGENERATION; EXPRESSION; INVITRO;
Keywords:
WALLERIAN DEGENERATION; MACROPHAGES; MYELIN PHAGOCYTOSIS; PENTOXIFYLLINE (POX);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M. Liefner et al., "CONCENTRATION-DEPENDENT EFFECTS OF PENTOXIFYLLINE ON MIGRATION AND MYELIN PHAGOCYTOSIS BY MACROPHAGES", Journal of neuroimmunology, 89(1-2), 1998, pp. 97-103

Abstract

The effects of pentoxifylline (POX) on macrophage migration and myelin uptake were studied in an in vitro model of myelin phagocytosis. ThePOX is a phosphodiesterase inhibitor which inhibits TNF-alpha (tumor necrosis factor alpha) production and reduces ICAM-1 (intercellular adhesion molecule-1) expression by macrophages. Both of these molecules have earlier been shown to be involved in the process of myelin recognition and degradation. In the present series of experiments, cocultured peripheral nerves and macrophages were treated with different concentrations of POX. Untreated controls were massively invaded by macrophages which ingested the degenerating myelin sheaths. High concentrations of POX (100 mu g ml(-1)) inhibited macrophage invasion of the nerves. Lower POX concentrations (50 mu g ml(-1)), in contrast, lead to an increased myelin uptake by phagocytic cells without affecting macrophage migration. These data indicate that POX may regulate different effector functions of macrophages such as migration and myelin phagocytosisduring Wallerian degeneration. This is important for inflammatory demyelinating conditions in the central or peripheral nervous system (PNS) in which macrophages are also important effector cells. Since POX isused as an immunomodulatory drug in demyelinating diseases, its effects on the described macrophage functions may be of high relevance. An increased myelin uptake during Wallerian degeneration may also supporta more efficient axonal regeneration by removing axonal outgrowth inhibitors. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:23:50