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Titolo:
DEVELOPMENT OF COLONIC ADENOCARCINOMAS IN A MOUSE MODEL OF ULCERATIVE-COLITIS
Autore:
SHAH SA; SIMPSON SJ; BROWN LF; COMISKEY M; DEJONG YP; ALLEN D; TERHORST C;
Indirizzi:
HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DIV IMMUNOL,330 BROOKLINE AVE BOSTON MA 02215 HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DIV IMMUNOL BOSTONMA 02215 HARVARD UNIV,SCH MED,BETH ISRAEL DEACONESS MED CTR,DEPT PATHOL BOSTONMA 02215
Titolo Testata:
Inflammatory bowel diseases
fascicolo: 3, volume: 4, anno: 1998,
pagine: 196 - 202
SICI:
1078-0998(1998)4:3<196:DOCAIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; CHRONIC INTESTINAL INFLAMMATION; CD4(+) T-CELLS; INTERLEUKIN-10-DEFICIENT MICE; CROHNS-DISEASE; SCID MICE; CANCER; DYSPLASIA; GENE; RISK;
Keywords:
INFLAMMATORY BOWEL DISEASE (IBD); ULCERATIVE COLITIS; INTERLEUKIN-2; BETA(2)-MICROGLOBULIN; ADENOCARCINOMA; INTERFERON; CD4(+) T CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Shah et al., "DEVELOPMENT OF COLONIC ADENOCARCINOMAS IN A MOUSE MODEL OF ULCERATIVE-COLITIS", Inflammatory bowel diseases, 4(3), 1998, pp. 196-202

Abstract

Mice deficient in both interleukin-2 and beta(2)-microglobulin expression (beta(2)m(null) x IL-2(null) mice) develop an inflammatory disease of the colon resembling ulcerative colitis. To examine long-term complications of disease in these mice, a group of 34 beta(2)m(null) x IL-2(null) mice was monitored for 6-12 months. Development of clinical disease was assessed by wasting, general appearance, and diarrhea. Further analysis included histologic examination of the distal colon for colitis, staining of CD4(+) T cells for surface activation markers, andcytoplasmic staining of CD4(+) T cells for IFN-gamma and TNF-alpha. These older beta(2)m(null) x IL-2(null) mice had activated CD4(+) T cells as assessed by surface markers on flow cytometry. Cytoplasmic staining revealed IFN-gamma production, but not TNF-alpha production by CD4(+) T cells. The majority of these older beta(2)m(null) x IL-2(null) mice continued to have colitis on histology. However, they lived much longer and had less wasting in comparison to IL-2(null) mice. At necropsy, 11 (32%) of 34 of the beta(2)m(null) x IL-2(null) mice had tumors in the proximal half of the colon. Histologic examination confirmed these tumors to be adenocarcinomas. These mice may be useful as a model for studying carcinogenesis in chronic colitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:01:19