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Titolo:
EDRF NO AND ENDOTHELIAL FUNCTION - AN UPD ATE/
Autore:
DELONCA J; BALTEAUX V; GIRAUD T; SANCHEZ RY;
Indirizzi:
LABS HOECHST,DEPT DEV,TOUR ROUSSEL HOECHST F-92080 PARIS 03 FRANCE
Titolo Testata:
Archives des maladies du coeur et des vaisseaux
fascicolo: 11, volume: 86, anno: 1993,
pagine: 1617 - 1624
SICI:
0003-9683(1993)86:11<1617:ENAEF->2.0.ZU;2-7
Fonte:
ISI
Lingua:
FRE
Soggetto:
NITRIC-OXIDE; VASCULAR ENDOTHELIUM; RELAXING FACTOR; DEPENDENT RELAXATION; ARTERIES; DYSFUNCTION; RELEASE; ATHEROSCLEROSIS; VASODILATION; PLATELETS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Delonca et al., "EDRF NO AND ENDOTHELIAL FUNCTION - AN UPD ATE/", Archives des maladies du coeur et des vaisseaux, 86(11), 1993, pp. 1617-1624

Abstract

Our appreciation of the vascular endothelium has changed considerablyover the last decade. This organ, finally recognised as such, participates actively in vasomotor regulation and haemostasis. It secretes several relaxing and contracting factors which act locally to determine resting vascular tone. One of the relaxing factors, EDRF/NO plays an important physiological role as it contributes to the rapid adaptation of blood flow to various pharmacological and mechanical stimuli, thereby ensuring maintenance of adequate tissue perfusion. Nitric oxide (NO) is an ubiquitous factor which was crowned ''molecule of the year 1992'' by the scientific review Science. Its effects extend well beyond those on the cardiovascular system. Endothelial dysfunction is observedin many pathological states such as atherosclerosis, reperfusion injury, post-angioplasty endothelial regeneration, degeneration of venous bypass grafts, pure spastic angina, hypertension and diabetes. It is associated with decreased production of EDRF/NO, which probably contributes significantly to the aggravation of endothelial and parietal lesions and to the natural progression of atherosclerotic disease in general. This article describes the principal vasoactive factors secreted by the endothelium and goes on to list the physiologic cardiovascular effects of EDRF/NO in detail, and to review the different pathologies associated with a disorder of secretion of this factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 00:33:21