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Titolo:
2',3'-O-PHOSPHONOALKYLIDENE DERIVATIVES OF RIBONUCLEOSIDES - SYNTHESIS AND REACTIVITY
Autore:
ENDOVA M; MASOJIDKOVA M; BUDESINSKY M; ROSENBERG I;
Indirizzi:
ACAD SCI CZECH REPUBL,INST ORGAN CHEM & BIOCHEM,FLEMINGOVO NAM 2 CR-16610 PRAGUE 6 CZECH REPUBLIC ACAD SCI CZECH REPUBL,INST ORGAN CHEM & BIOCHEM CR-16610 PRAGUE 6 CZECH REPUBLIC
Titolo Testata:
Tetrahedron
fascicolo: 37, volume: 54, anno: 1998,
pagine: 11151 - 11186
SICI:
0040-4020(1998)54:37<11151:2DOR-S>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-HIV ACTIVITY; PHOSPHONATE ANALOGS; C-13 NMR; CONFORMATION; NUCLEOSIDES; SPECTRUM; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M. Endova et al., "2',3'-O-PHOSPHONOALKYLIDENE DERIVATIVES OF RIBONUCLEOSIDES - SYNTHESIS AND REACTIVITY", Tetrahedron, 54(37), 1998, pp. 11151-11186

Abstract

A novel type of nucleotide analogues, the 2',3'-O-(1-diethylphosphono)alkylidene derivatives of ribonucleosides was prepared by redox reaction of diethyl chlorophosphite with various nucleoside orthoesters. Some of these compounds undergo interesting rearrangements when treated with nucleophiles. The configuration of the title compounds was determined by 2D-ROESY experiments. Biological activity of partially protected nucleotide analogues is also discussed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:21:42