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Titolo:
EARLY ISCHEMIA-INDUCED ALTERATIONS OF THE OUTER MITOCHONDRIAL-MEMBRANE AND THE INTERMEMBRANE SPACE - A POTENTIAL CAUSE FOR ALTERED ENERGY-TRANSFER IN CARDIAC-MUSCLE
Autore:
ROSSI A; KAY L; SAKS V;
Indirizzi:
UNIVERSITE JOSEPH FOURIER,LAB BIOENERGET,BP 53X F-38041 GRENOBLE 9 FRANCE INST CHEM & BIOL PHYS,LAB BIOENERGET TALLINN ESTONIA
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 1-2, volume: 184, anno: 1998,
pagine: 401 - 408
SICI:
0300-8177(1998)184:1-2<401:EIAOTO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-HEART MITOCHONDRIA; CREATINE-KINASE; MYOCARDIAL-ISCHEMIA; CELLULAR RESPIRATION; CONTRACTILE FAILURE; IN-VIVO; METABOLISM; COMPARTMENTATION; REPERFUSION; PHOSPHATE;
Keywords:
MITOCHONDRIAL FUNCTION; ISCHEMIA; OUTER MEMBRANE; CREATINE; ENERGY AND SIGNAL CHANNELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A. Rossi et al., "EARLY ISCHEMIA-INDUCED ALTERATIONS OF THE OUTER MITOCHONDRIAL-MEMBRANE AND THE INTERMEMBRANE SPACE - A POTENTIAL CAUSE FOR ALTERED ENERGY-TRANSFER IN CARDIAC-MUSCLE", Molecular and cellular biochemistry, 184(1-2), 1998, pp. 401-408

Abstract

Our aim was to carefully analyse the time-dependent changes that affect the mitochondrial function of myocardial cells during and after an ischemic episode. To this end, variables characterizing mitochondrial function have been evaluated on myocardial samples, from isolated rat hearts subjected to different conditions of ischemia. The technique ofpermeabilized fibers was used in order to evaluate the mitochondrial function whilst retaining intracellular structure. The earliest alteration that could be detected was a decrease in the stimulatory effect of creatine on mitochondrial respiration. This alteration became more pronounced as the severity (or duration) of the ischemia increased. Afterwards, a significant decrease in the apparent K-m of mitochondrial respiration for ADP also appeared, followed by a diminution of the maximal respiration rate which was pal;ly restored by adding cytochrome c. Finally, for the most severe conditions of ischemia, the basal respiratory rate also increased. These observations are indicative of a sequence of alterations affecting first the intermembrane space, then the outer mitochondrial membrane, and finally the inner membrane. The discussion is focused on the very early alterations, that could not be detected using the conventional techniques of isolated mitochondria. We postulate that these alterations to the intermembrane space and outer mitochondrial membrane can induce disturbances both in the channelling of energy from the mitochondria, and on the signalling towards the mitochondria. The potential consequences on the regulation of the production of energy (ATP, PC) by the mitochondria are evoked.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 23:46:19