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Titolo:
CHEMICALLY-INDUCED ANEUPLOIDY - INVESTIGATIONS INTO CHROMOSOME-SPECIFIC EFFECTS IN MITOSIS
Autore:
BOURNER RDP; PARRY EM; PARRY JM;
Indirizzi:
UNIV COLL SWANSEA,SCH BIOL SCI,CTR MOL GENET & TOXICOL,SINGLETON PK SWANSEA SA2 8PP W GLAM WALES UNIV COLL SWANSEA,SCH BIOL SCI,CTR MOL GENET & TOXICOL SWANSEA SA2 8PP W GLAM WALES
Titolo Testata:
Mutation research. Fundamental and molecular mechanisms of mutagenesis
fascicolo: 1-2, volume: 404, anno: 1998,
pagine: 191 - 197
SICI:
1386-1964(1998)404:1-2<191:CA-IIC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACROCENTRIC CHROMOSOMES; MICRONUCLEI;
Keywords:
ANEUPLOIDY; MITOSIS; ANEUGEN; HYBRID CELL; CHROMOSOME SPECIFICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
R.D.P. Bourner et al., "CHEMICALLY-INDUCED ANEUPLOIDY - INVESTIGATIONS INTO CHROMOSOME-SPECIFIC EFFECTS IN MITOSIS", Mutation research. Fundamental and molecular mechanisms of mutagenesis, 404(1-2), 1998, pp. 191-197

Abstract

Genotoxicity studies of aneuploidy may potentially produce different results depending upon the chromosome selected for analysis if chromosome-specific sensitivities to chemical exposure exist. Any chromosome specificity characteristics that predispose to aneuploidy might interact with environmental exposures in additional different ways related to the mechanism of aneuploidy induction. Thus, we have undertaken an investigation of chromosome-specific effects using morphologically distinct chromosomes in a hybrid cell line. We were able to identify eightdifferent chromosomes simultaneously by dual colour FISH analysis in controls and in cells exposed to a range of griseofulvin concentrations. Certain chromosomes were more frequently involved in aneuploidy, but no simple relationship between chromosome organisation and sensitivity emerged apart from the over-representation of the alien human chromosome. Aneuploidy was detected at higher frequencies in interphase cells compared with metaphase cells. Overall the data indicate that chemically induced aneuploidy may be detected for a variety of chromosomes and cell types using both interphase and metaphase protocols. However,the data obtained should be used with care in the hazard evaluation of chemical aneugens. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 08:45:03