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Titolo:
CONFORMATIONAL FLEXIBILITY AND RECEPTOR INTERACTION
Autore:
JANSSEN LHM;
Indirizzi:
UNIV UTRECHT,FAC PHARM,DEPT MED CHEM,POB 80082 NL-3508 TB UTRECHT NETHERLANDS
Titolo Testata:
Bioorganic & medicinal chemistry
fascicolo: 6, volume: 6, anno: 1998,
pagine: 785 - 788
SICI:
0968-0896(1998)6:6<785:CFARI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING;
Keywords:
CONFORMATIONAL FLEXIBILITY; RECEPTOR INTERACTION; RECEPTOR BOUND CONFORMATION; FREE ENERGY OF BINDING; CONFORMATIONAL ENERGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
L.H.M. Janssen, "CONFORMATIONAL FLEXIBILITY AND RECEPTOR INTERACTION", Bioorganic & medicinal chemistry, 6(6), 1998, pp. 785-788

Abstract

This theoretical analysis shows that the experimentally observed standard Gibbs free energy of binding of a ligand by a receptor can be described by two terms. One term describes the free energy of binding of the drug to the receptor when both are in their lowest energy conformation. The second term gives the difference between the average and thelowest conformational energy of the two species involved. It also follows that all drug molecules having an energy higher than the minimum energy, must have a higher affinity than molecules occurring in the minimum energy conformation, independent of the energy level of the receptor bound conformation. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 17:00:28