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Titolo:
AN ORALLY-ADMINISTERED GROWTH-FACTOR EXTRACT DERIVED FROM BOVINE WHEYSUPPRESSES BREATH ETHANE IN COLITIC RATS
Autore:
PORTER SN; HOWARTH GS; BUTLER RN;
Indirizzi:
WOMENS & CHILDRENS HOSP,GASTROENTEROL UNIT,72 KING WILLIAM RD ADELAIDE SA 5006 AUSTRALIA WOMENS & CHILDRENS HOSP,GASTROENTEROL UNIT ADELAIDE SA 5006 AUSTRALIA UNIV ADELAIDE,DEPT PHYSIOL ADELAIDE SA 5005 AUSTRALIA S AUSTRALIA COOPERAT RES CTR TISSUE GROWTH & REPA ADELAIDE SA AUSTRALIA WOMENS & CHILDRENS HOSP,CHILD HLTH RES INST ADELAIDE SA 5006 AUSTRALIA
Titolo Testata:
Scandinavian journal of gastroenterology
fascicolo: 9, volume: 33, anno: 1998,
pagine: 967 - 974
SICI:
0036-5521(1998)33:9<967:AOGEDF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; REACTIVE OXYGEN METABOLITES; CHEESE WHEY; GASTROINTESTINAL-TRACT; LIPID-PEROXIDATION; ULCERATIVE-COLITIS; INDUCTION; PENTANE; PROTEIN;
Keywords:
BREATH TESTING; ETHANE; GROWTH FACTORS; RATS; ULCERATIVE COLITIS; WHEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Porter et al., "AN ORALLY-ADMINISTERED GROWTH-FACTOR EXTRACT DERIVED FROM BOVINE WHEYSUPPRESSES BREATH ETHANE IN COLITIC RATS", Scandinavian journal of gastroenterology, 33(9), 1998, pp. 967-974

Abstract

Background: Lipid peroxidation is a potential mechanism of bowel damage in colitis. The effect of oral consumption of a bovine whey-derivedgrowth factor extract (WGFE) on lipid peroxidation was assessed usingthe ethane breath test in the dextran sulphate sodium (DSS) model of ulcerative colitis (UC) in rats. Methods: Groups of rats consumed water (control), 2% DSS in drinking water, 2% DSS with a WGFE-supplementeddiet, or 2% DSS plus prednisolone (1 mg . kg(-1) . day(-1)) for 6 weeks, changing to sulphasalazine (100 mg . kg(-1) . day(-1)) for the subsequent 4 weeks. Ethane breath tests were conducted on all animals on days 2, 4, 6, 8, and 10 (acute phase) and weeks 3, 6, and 9 (chronic phase) after commencement of DSS consumption. Results: There were no significant differences in ethane production between any groups during the acute phase. Ethane was significantly increased (P < 0.05) in rats consuming DSS alone in week 6 compared with control but had decreased to control levels by week 9. WGFE and conventional therapy were effective in suppressing ethane production in week 3. Conclusions: WGFE is as effective as conventional therapies at limiting ethane production and thus ostensibly colonic lipid peroxidation in the early phases of experimental chronic UC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 08:04:21