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Titolo:
MRI THERMOMETRY IN PHANTOMS BY USE OF THE PROTON-RESONANCE FREQUENCY-SHIFT METHOD - APPLICATION TO INTERSTITIAL LASER THERMOTHERAPY
Autore:
OLSRUD J; WIRESTAM R; BROCKSTEDT S; NILSSON AMK; TRANBERG KG; STAHLBERG F; PERSSON BRR;
Indirizzi:
UNIV LUND HOSP,DEPT RADIAT PHYS SE-22185 LUND SWEDEN UNIV LUND HOSP,DEPT DIAGNOST RADIOL SE-22185 LUND SWEDEN UNIV LUND HOSP,DEPT SURG SE-22185 LUND SWEDEN LUND INST TECHNOL,DEPT PHYS SE-22100 LUND SWEDEN
Titolo Testata:
Physics in medicine and biology
fascicolo: 9, volume: 43, anno: 1998,
pagine: 2597 - 2613
SICI:
0031-9155(1998)43:9<2597:MTIPBU>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERATURE DISTRIBUTION; OPTICAL-PROPERTIES; TISSUE; HYPERTHERMIA; SPECTROSCOPY; PHASE; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
J. Olsrud et al., "MRI THERMOMETRY IN PHANTOMS BY USE OF THE PROTON-RESONANCE FREQUENCY-SHIFT METHOD - APPLICATION TO INTERSTITIAL LASER THERMOTHERAPY", Physics in medicine and biology, 43(9), 1998, pp. 2597-2613

Abstract

In this work the temperature dependence of the proton resonance frequency was assessed in agarose gel with a high melting temperature (95 degrees C) and in porcine liver in vitro at temperatures relevant to thermotherapy (25-80 degrees C). Furthermore, an optically tissue-like agarose gel phantom was developed and evaluated for use in MRI. The phantom was used to visualize temperature distributions from a diffusing laser fibre by means of the proton resonance frequency shift method. An approximately linear relationship (0.0085 ppm degrees C-1) between proton resonance frequency shift and temperature change was found for agarose gel, whereas deviations from a linear relationship were observed for porcine liver. The optically tissue-like agarose gel allowed reliable MRI temperature monitoring, and the MR relaxation times (T-1 andT-2) and the optical properties were found to be independently alterable. Temperature distributions around a diffusing laser fibre, during irradiation and subsequent cooling, were assessed with high spatial resolution (voxel size = 4.3 mm(3)) and with random uncertainties ranging from 0.3 degrees C to 1.4 degrees C (1 SD) with a 40 s scan time.

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Documento generato il 04/07/20 alle ore 11:59:54