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Titolo:
THE VALUE OF INTERPHASE CYTOGENETICS IN CYTOLOGY FOR THE DIAGNOSIS OFLEPTOMENINGEAL METASTASES
Autore:
VANOOSTENBRUGGE RJ; HOPMAN AHN; ARENDS JW; RAMAEKERS FCS; TWIJNSTRA A;
Indirizzi:
UNIV HOSP MAASTRICHT,DEPT NEUROL,POB 5800 NL-6202 AZ MAASTRICHT NETHERLANDS UNIV MAASTRICHT,DEPT MOL GENET & CELL BIOL MAASTRICHT NETHERLANDS UNIV HOSP MAASTRICHT,DEPT PATHOL MAASTRICHT NETHERLANDS
Titolo Testata:
Neurology
fascicolo: 3, volume: 51, anno: 1998,
pagine: 906 - 908
SICI:
0028-3878(1998)51:3<906:TVOICI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; CELLS; DNA; CYTOMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Vanoostenbrugge et al., "THE VALUE OF INTERPHASE CYTOGENETICS IN CYTOLOGY FOR THE DIAGNOSIS OFLEPTOMENINGEAL METASTASES", Neurology, 51(3), 1998, pp. 906-908

Abstract

We studied the use of fluorescence in situ hybridization (FISH) in CSF to enhance the diagnostic yield for the detection of malignancy on the first; lumbar puncture in patients clinically suspected of having leptomeningeal metastases (LMM). Although repeated lumbar punctures were still needed in some patients, the use of FISH did speed up the diagnosis in approximately one-third of the patients clinically suspected of having LMM with atypical cells at first cytology. This eliminates the need for repeated lumbar punctures in these patients and enables anearlier start of treatment.

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Documento generato il 30/11/20 alle ore 17:05:02