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Titolo:
COMPARISON OF IODOTYROSINES AND METHIONINE UPTAKE IN A RAT GLIOMA MODEL
Autore:
LANGEN KJ; CLAUSS RP; HOLSCHBACH M; MUHLENSIEPEN H; KIWIT JCW; ZILLES K; COENEN HH; MULLERGARTNER HW;
Indirizzi:
RES CTR,INST MED,POB 1913 D-52425 JULICH GERMANY RES CTR,INST NUCL CHEM JULICH GERMANY UNIV DUSSELDORF,DEPT NEUROSURG D-4000 DUSSELDORF GERMANY UNIV DUSSELDORF,DEPT NEUROANAT D-4000 DUSSELDORF GERMANY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 9, volume: 39, anno: 1998,
pagine: 1596 - 1599
SICI:
0161-5505(1998)39:9<1596:COIAMU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-TRANSPORT; BRAIN-TUMORS; L-3-)I-123>IODO-ALPHA-METHYL TYROSINE; COMPUTED-TOMOGRAPHY; PROTEIN-SYNTHESIS; IN-VIVO; PET; SPECT; COMPETITION;
Keywords:
AMINO ACIDS; 3-[I-123]IODO-ALPHA-METHYL-L-TYROSINE; 3[I-123/125]IODO-O-METHYL-ALPHA-METHYL-L-TYROSINE; [METHYL-H-3]-L-METHIONINE; CEREBRAL GLIOMA; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Langen et al., "COMPARISON OF IODOTYROSINES AND METHIONINE UPTAKE IN A RAT GLIOMA MODEL", The Journal of nuclear medicine, 39(9), 1998, pp. 1596-1599

Abstract

This study compares brain tumor imaging with 3-[I-123]iodo-oc-methyl-l-tyrosine (IMT) and -[I-123/1'25]iodo-O-methyl-alpha-methyl-l-tyrosine (OMIMT) to that with [methyl-H-3]-L-methionine (Met) in a rat gliomamodel by double-tracer autoradiography. Methods: Cells of the glioma clone F-98 were implanted stereotactically into the right basal ganglia of 22 Fischer 344 rats. After 8 days of tumor growth, the animals simultaneously were injected with a mixture of either I-123-IMT and H-3-Met (n = 5), I-123-OMIMT and H-3-Met (n = 8) or I-123-IMT and I-125-OMIMT (n = 9). The animals were killed 15 min after the tracer injectionand cryosections of the tumor-bearing brain area were exposed to phosphor-imaging plates both immediately and after the decay of I-123. Tumor-to-brain ratios (T/B) and intratumoral distribution of the different tracers and of the cresyl violet staining of the tissue were compared. Results: There was a significant correlation of the T/B ratios between all tracers (IMT versus Met: r = 0.97, n = 5, p < 0.01; OMIMT versus Met: r = 0.94, n = 8, p < 0.001; OMIMT versus IMT: r = 0.95, n = 9,p < 0.001). Intratumoral tracer distribution was similar for all tracers and the extent of tumor labeling was identical to that of the histological tumor extent. Mean values of the T/B ratios, however, were lower for IMT (2.81 +/- 0.78, n = 14 mean +/- s.d., p < 0.01 compared with Met) and for OMIMT (2.03 +/- 0.57, n = 17, p < 0.01 compared with Met) than for Met (3.86 +/- 1.12, n = 13). Conclusion: This study confirms that tumor imaging with IMT is similar to that of Met but T/B ratios of IMT are lower. OMIMT intratumoral tracer distribution and tumor size are similar to Met and IMT, but the T/B contrast is rather low and makes this amino acid less suitable for clinical application.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 06:56:07