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Titolo:
ADVERSE NEUROBIOLOGICAL EFFECTS OF LONG-TERM USE OF NEUROLEPTICS - HUMAN AND ANIMAL STUDIES
Autore:
JESTE DV; LOHR JB; EASTHAM JH; ROCKWELL E; CALIGIURI MP;
Indirizzi:
UNIV CALIF SAN DIEGO SAN DIEGO CA 92103 VET AFFAIRS MED CTR SAN DIEGO CA 92161
Titolo Testata:
Journal of Psychiatric Research
fascicolo: 3-4, volume: 32, anno: 1998,
pagine: 201 - 214
SICI:
0022-3956(1998)32:3-4<201:ANEOLU>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUG-INDUCED PARKINSONISM; CAUDATE NUCLEI VOLUMES; TARDIVE-DYSKINESIA; SCHIZOPHRENIC-PATIENTS; PSYCHIATRIC-SYMPTOMS; ANTIPSYCHOTIC-DRUGS; COGNITIVE FUNCTIONS; RAT STRIATUM; CELL LOSS; CLOZAPINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
D.V. Jeste et al., "ADVERSE NEUROBIOLOGICAL EFFECTS OF LONG-TERM USE OF NEUROLEPTICS - HUMAN AND ANIMAL STUDIES", Journal of Psychiatric Research, 32(3-4), 1998, pp. 201-214

Abstract

Neuroleptics have revolutionized the treatment of schizophrenia and other psychoses since the early 1950s. Several adverse neurobiological effects are, however, associated with the long-term use of these agents. This article will review human and animal studies of these adverse effects, and also present some new data. Tardive dyskinesia (TD) is the most widely studied potentially persistent movement disorder resulting from long-term neuroleptic treatment, and several risk factors for TD development have been identified. Although drug-induced parkinsonism (DIP) usually disappears after the offending agent is withdrawn, a small portion of patients may have persistent parkinsonism. It is however, unclear if this is an aging-related effect. Persistent cognitive impairment associated with long-term use of typical neuroleptics has not been well documented. Atypical antipsychotics may produce improvement in cognitive performance in patients with chronic schizophrenia. MRIchanges that are secondary to neuroleptics are possible, but have notyet been studied adequately. There is one unconfirmed report of neurofibrillary tangles associated with longterm neuroleptic use. A number of investigators have reported vacuous chewing movements, and neuropathologic changes following prolonged administration of neuroleptics in animals. We discuss the implications of the various reported adverse effects of long-term use of neuroleptics. Published by Elsevier ScienceLtd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:21:15