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Titolo:
MODE OF ACTION OF LINENSCIN OC2 AGAINST LISTERIA-INNOCUA
Autore:
BOUCABEILLE C; LETELLIER L; SIMONET JM; HENCKES G;
Indirizzi:
UNIV PARIS 11,CNRS,URA 2225,INST MICROBIOL & GENET,BATIMENT 360 F-91405 ORSAY 05 FRANCE UNIV PARIS 11,CNRS,URA 2225,INST MICROBIOL & GENET F-91405 ORSAY 05 FRANCE UNIV PARIS 11,CNRS,URA 1116,LAB BIOMEMBRANES F-91405 ORSAY 05 FRANCE
Titolo Testata:
Applied and environmental microbiology
fascicolo: 9, volume: 64, anno: 1998,
pagine: 3416 - 3421
SICI:
0099-2240(1998)64:9<3416:MOAOLO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESCHERICHIA-COLI-CELLS; BREVIBACTERIUM-LINENS; CYTOPLASMIC MEMBRANE; MONOCYTOGENES SCOTT; LOW-TEMPERATURES; FATTY-ACID; RAW-MILK; BACTERIOCIN; ANTIBACTERIAL; CHANNELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Boucabeille et al., "MODE OF ACTION OF LINENSCIN OC2 AGAINST LISTERIA-INNOCUA", Applied and environmental microbiology, 64(9), 1998, pp. 3416-3421

Abstract

Linenscin OC2 is a small hydrophobic substance produced by the orangecheese coryneform bacterium Brevibacterium linens OC2, Linenscin OC2 inhibits growth of gram-negative bacteria with an altered outer membrane permeability and gram-positive bacteria. It is also able to lyse eucaryotic cells. The mode of action of linenscin OC2 on the Listeria innocua cytoplasmic membrane and the effects of environmental parameterswere investigated. Addition of low doses of linenscin OC2 resulted inan immediate perturbation of the permeability properties of the cytoplasmic membrane and of the bacterial energetic state. Linenscin OC2 induced a loss of cytoplasmic potassium, depolarization of the cytoplasmic membrane, complete hydrolysis of internal ATP, efflux of inorganic phosphate, and transient increase in oxygen consumption, Potassium loss occurred in the absence of a proton motive force and was severely reduced at low temperatures, presumably as a result of increased ordering of the lipid hydrocarbon chains of the cytoplasmic membrane. We propose that linenscin OC2 interacts with the cytoplasmic membrane and that the permeability changes observed at low doses reflect the formationof pore-like structures in this membrane.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 01:27:54