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Titolo:
IMPROVEMENT IN INNER-EAR BLOOD-FLOW BY NITRIC-OXIDE FOLLOWING EXPERIMENTALLY-INDUCED COCHLEAR THROMBOSIS IN ANESTHETIZED GUINEA-PIGS
Autore:
HAUPT H; SCHEIBE F; REBENTISCH E;
Indirizzi:
HUMBOLDT UNIVERSITAT BERLIN,KLINIKUM CHARITE,HALS NASEN OHREN KLIN,SCHUMANNSTR 20-21 D-10117 BERLIN GERMANY HUMBOLDT UNIVERSITAT BERLIN,KLINIKUM CHARITE,HALS NASEN OHREN KLIN D-10117 BERLIN GERMANY
Titolo Testata:
European archives of oto-rhino-laryngology
fascicolo: 7, volume: 255, anno: 1998,
pagine: 334 - 339
SICI:
0937-4477(1998)255:7<334:IIIBBN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASER-DOPPLER MEASUREMENTS; SODIUM-NITROPRUSSIDE; VASODILATING AGENTS; TOPICAL APPLICATION; SYNTHASE; LOCALIZATION; ANESTHESIA; RESPONSES; GERBIL; MICE;
Keywords:
LASER DOPPLER FLOWMETRY; COCHLEAR THROMBOSIS; NITRIC OXIDE; ANESTHESIA; GUINEA PIG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
H. Haupt et al., "IMPROVEMENT IN INNER-EAR BLOOD-FLOW BY NITRIC-OXIDE FOLLOWING EXPERIMENTALLY-INDUCED COCHLEAR THROMBOSIS IN ANESTHETIZED GUINEA-PIGS", European archives of oto-rhino-laryngology, 255(7), 1998, pp. 334-339

Abstract

The nitric oxide (NO) donor sodium nitroprusside (SNP) applied to theround window membrane has recently been found to increase cochlear blood flow (CoBF) in normal guinea pigs and in normal and presbyacusic mice. This study examined the effect of topical applications of SNP on experimentally impaired CoBF in anesthetized guinea pigs. Small (3 mu l) portions of 3% SNP were applied to the round window niche of both normal and thrombosed cochleas. Local vascular impairment was produced by ferromagnetic thrombosis of cochlear blood vessels and the microcirculation measured using laser Doppler flowmetry. Ferromagnetic thrombosis resulted in a mean decrease of CoBF to 52% of baseline. There was a clear improvement in mean CoBF to 84% of baseline by the topical application of SNP that depended on the degree of ischemic damage produced. Under neuroleptanalgesia and ketamine-xylazine anesthesia, significant increases in CoBF were measured in normal ears as well as in the thrombosed ones. However, several SNP applications were needed to improve the impaired CoBF, while a single portion was sufficient in the normal cochlea to cause a drastic increase in mean CoBF to 84% of baseline. In urethane-anesthetized animals, no flow increase was found despite repeated drug administration. Careful evaluation of the laser Doppler signals was necessary to accurately determine the concentrations of the moving blood cells and their mean velocities.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:04:20