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Titolo:
STEREOSELECTIVE BINDING OF KETOPROFEN ENANTIOMERS TO HUMAN SERUM-ALBUMIN STUDIED BY HIGH-PERFORMANCE LIQUID AFFINITY-CHROMATOGRAPHY
Autore:
ZHIVKOVA ZD; RUSSEVA VN;
Indirizzi:
MED UNIV SOFIA,FAC PHARM,DEPT CHEM,2 DUNAV ST SOFIA 1000 BULGARIA
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 2, volume: 714, anno: 1998,
pagine: 277 - 283
SICI:
0378-4347(1998)714:2<277:SBOKET>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PLASMA-PROTEIN BINDING; CIRCULAR-DICHROISM; STATIONARY-PHASE; OCTANOIC-ACID; SITES; CYCLOOXYGENASE; FLURBIPROFEN; INHIBITION; KETOROLAC;
Keywords:
ENANTIOMER SEPARATION; KETOPROFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Z.D. Zhivkova e V.N. Russeva, "STEREOSELECTIVE BINDING OF KETOPROFEN ENANTIOMERS TO HUMAN SERUM-ALBUMIN STUDIED BY HIGH-PERFORMANCE LIQUID AFFINITY-CHROMATOGRAPHY", Journal of chromatography B. Biomedical sciences and applications, 714(2), 1998, pp. 277-283

Abstract

A chiral stationary phase based on immobilized human serum albumin (HSA) was used to study the stereoselective binding of ketoprofen enantiomers by means of high-performance liquid affinity chromatography. Thetechnique of zonal elution was applied together with a never mathematical approach describing attachment to more than one type of binding site. Phenylbutazon (PBZ) and diazepam (DAZ) were used as markers for the major believed binding regions on HSA. Both R- and S-ketoprofen (KTR and KTS) display high affinity to the primary PBZ- and DAZ-binding sites and low-affinity to the secondary DAZ sites. The binding to high-affinity regions is accepted to be a stepwise process initiated by thebinding to the primary DAZ sites and followed by the attachment to the primary PBZ sites. The chiral recognition is attributed to the high-affinity PBZ-binding sites and to the low-affinity DAZ-binding sites. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:29:42