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Titolo:
DRUG ACCUMULATION IN MELANIN - AN AFFINITY CHROMATOGRAPHIC STUDY
Autore:
KNORLE R; SCHNIZ E; FEUERSTEIN TJ;
Indirizzi:
UNIV FREIBURG,NEUROZENTRUM,NEUROL KLIN,SEKT KLIN NEUROPHARMAKOL,BREISACHER STR 64 D-79106 FREIBURG GERMANY IBAM D-79102 FREIBURG GERMANY
Titolo Testata:
Journal of chromatography B. Biomedical sciences and applications
fascicolo: 2, volume: 714, anno: 1998,
pagine: 171 - 179
SICI:
0378-4347(1998)714:2<171:DAIM-A>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING; NEUROMELANIN; TRYPSIN; LIGANDS;
Keywords:
MELANIN; CHLOROQUINE; HALOPERIDOL; ZOTEPIN; TRIMIPRAMINE; DESIPRAMINE; SULPIRIDE; CLONAZEPAM; FLUNITRAZEPAM; BENZODIAZEPINE METABOLITES; BENZOPHENONES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R. Knorle et al., "DRUG ACCUMULATION IN MELANIN - AN AFFINITY CHROMATOGRAPHIC STUDY", Journal of chromatography B. Biomedical sciences and applications, 714(2), 1998, pp. 171-179

Abstract

The affinity of several drugs to melanin has been indirectly assessedusing an affinity chromatographic approach based on immobilized melanin. Plots of the retention of the drugs on the affinity column versus the number of molecules applied were fitted best by nonlinear, exponential curves characteristic for each drug. These curves reflect the complexity of the binding behaviour, consisting of a variety of hydrogen bonding, hydrophobic or ionic interactions as well as cooperative or anti-cooperative interactions between the drug molecules and melanin. The nonlinear fitting procedure was based on a descriptive function andallowed to discriminate the binding behaviour according to parameter estimates which specified the investigated drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:30:23