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Titolo:
5-HT2A RECEPTOR BLOCKADE IN PATIENTS WITH SCHIZOPHRENIA TREATED WITH RISPERIDONE OR CLOZAPINE - A SPET STUDY USING THE NOVEL 5-HT2A LIGAND I-123 5-I-R-91150
Autore:
TRAVIS MJ; BUSATTO GF; PILOWSKY LS; MULLIGAN R; ACTON PD; GACINOVIC S; MERTENS J; TERRIERE D; COSTA DC; ELL PJ; KERWIN RW;
Indirizzi:
INST PSYCHIAT,DEPT PSYCHOL MED,SECT CLIN NEUROPHARMACOL,DE CRESPIGNY PK LONDON SE5 8AF ENGLAND INST NUCL MED LONDON ENGLAND VVB CYCLOTRON BRUSSELS BELGIUM
Titolo Testata:
British Journal of Psychiatry
, volume: 173, anno: 1998,
pagine: 236 - 241
SICI:
0007-1250(1998)173:<236:5RBIPW>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION TOMOGRAPHY; SCALE; HALOPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Travis et al., "5-HT2A RECEPTOR BLOCKADE IN PATIENTS WITH SCHIZOPHRENIA TREATED WITH RISPERIDONE OR CLOZAPINE - A SPET STUDY USING THE NOVEL 5-HT2A LIGAND I-123 5-I-R-91150", British Journal of Psychiatry, 173, 1998, pp. 236-241

Abstract

Background 5-HT2A receptor antagonism may be crucial to the action ofatypical antipsychotics. Previous work has related 5-HT2A receptor blockade to clinical efficacy and protection from extrapyramidal side-effects. Method We developed a SPET imaging protocol for assessing 5-HT2A receptor binding using the selective ligand I-123-5-I-R91150. Six healthy volunteers, five clozapine- and five risperidone-treated subjects with DSM - IV schizophrenia were studied. Multi-slice SPET was performed on each subject. Results Cortex:cerebellum ratios were significantly lower in both clozapine- and risperidone-treated subjects comparedwith the healthy volunteers in all cortical regions. There was no difference in occupancy between the two drug-treated groups. No correlation was found between-the percentage change in the Global Assessment Scale (GAS) and 5-HT2A receptor binding indices in the drug-treated groups. Conclusions Clozapine and risperidone potently block 5-HT2A receptors in vivo. The lack of relationship between receptor binding indicesand change in GAS suggests that 5-HT2A receptor blockade may be unrelated to clinical improvement. Future studies will substantiate this finding by studying 5-HT2A receptor binding in large groups of patients treated with both typical and novel atypical antipsychotics.

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Documento generato il 18/01/20 alle ore 08:14:56