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Titolo:
DISTRIBUTION OF PROGNOSTICALLY IMPORTANT VASCULAR PATTERNS ACROSS MULTIPLE LEVELS IN CILIARY BODY AND CHOROIDAL MELANOMAS
Autore:
MEHAFFEY MG; GARDNER LM; FOLBERG R;
Indirizzi:
UNIV IOWA,MED RES CTR,DEPT OPHTHALMOL & VISUAL SCI,ROOM 233 IOWA CITYIA 52242 UNIV IOWA,MED RES CTR,DEPT OPHTHALMOL & VISUAL SCI IOWA CITY IA 52242 UNIV IOWA,DEPT PATHOL IOWA CITY IA 52242
Titolo Testata:
American journal of ophthalmology
fascicolo: 3, volume: 126, anno: 1998,
pagine: 373 - 378
SICI:
0002-9394(1998)126:3<373:DOPIVP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEEDLE ASPIRATION BIOPSY; UVEAL MALIGNANT-MELANOMA; TUMOR PROGRESSION; BREAST-CARCINOMA; METASTASIS; PROGNOSIS; LECTURE; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Mehaffey et al., "DISTRIBUTION OF PROGNOSTICALLY IMPORTANT VASCULAR PATTERNS ACROSS MULTIPLE LEVELS IN CILIARY BODY AND CHOROIDAL MELANOMAS", American journal of ophthalmology, 126(3), 1998, pp. 373-378

Abstract

PURPOSE: To investigate the validity of assigning patients whose eyeshave been removed for ciliary body or choroidal melanoma to risk groups for metastasis based on the identification of microcirculatory patterns in one cross-section taken from the center of the tumor. METHODS:Multiple levels were cut through the blocks of 15 ciliary body or choroidal melanomas until the tumor was exhausted. Each level was examined for the presence of microvascular networks and parallel vessels withcross linking histologic features strongly associated with death frommetastatic melanoma. RESULTS: The central histologic section did not contain either microvascular networks or parallel vessels with cross-linking in eight tumors, nor were these patterns encountered in any of the more peripheral levels of the tumor. Seven tumors contained at least one focus of either microvascular networks or parallel vessels withcross-linking in the central histologic section. In two tumors, at least one of these patterns appeared in all histologic levels; in five tumors, at least one of these patterns appeared through multiple levelsuntil just before the tumor was exhausted from the block (0.24 to 0.85 mm from the edge of the tumor). CONCLUSIONS: This study suggests that the prognostic classification of uveal melanoma based on the histologic profile of the microcirculation may be consistent throughout the tumor depth, (C) 1998 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:17:33