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Titolo:
WAVES OF MOUSE LUNATIC FRINGE EXPRESSION, IN 4-HOUR CYCLES AT 2-HOUR INTERVALS, PRECEDE SOMITE BOUNDARY FORMATION
Autore:
FORSBERG H; CROZET F; BROWN NA;
Indirizzi:
ST GEORGE HOSP,SCH MED,DEPT ANAT & DEV BIOL,CRANMER TERRACE LONDON SW17 0RE ENGLAND ST GEORGE HOSP,SCH MED,DEPT ANAT & DEV BIOL LONDON SW17 0RE ENGLAND
Titolo Testata:
Current biology
fascicolo: 18, volume: 8, anno: 1998,
pagine: 1027 - 1030
SICI:
0960-9822(1998)8:18<1027:WOMLFE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-HOMOLOG; NOTCH; SOMITOGENESIS; SEGMENTATION; NEUROGENESIS; PATHWAY; CHICK; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
H. Forsberg et al., "WAVES OF MOUSE LUNATIC FRINGE EXPRESSION, IN 4-HOUR CYCLES AT 2-HOUR INTERVALS, PRECEDE SOMITE BOUNDARY FORMATION", Current biology, 8(18), 1998, pp. 1027-1030

Abstract

During somitogenesis, cells are recruited to the caudal presomitic mesoderm (PSM) from the primitive streak (and later the tail bud), whilesomites separate from the rostral end as epithelial cubes [1]. This is a regular process, one somite forming every 2 hours in the mouse, that can be simulated by clock and wavefront models [2]. The chick basichelix-loop-helix transcription factor encoded by c-hairy1 is expressed in dynamic waves in the PSM, undergoing one cycle for each somite formed [3]. This is compatible with an underlying oscillating molecular clock. We have shown here that Lunatic fringe (L-fng) expression is indicative of it being one of the implementing outputs of this clock. Fringe genes regulate the Notch signalling pathway in boundary formation[4,5]. Of the known mouse genes, only L-fng is expressed in PSM [4,5]and it is required for somite segmentation and patterning [6,7]. We have now shown that L-fng is expressed as dynamic, repetitive and complex waves within the mouse PSM. A wave takes 4 hours to complete one cycle and terminates immediately at, and prior to, somite boundary formation. Consecutive waves are temporally but not spatially overlapping, being initiated in the caudal PSM every 2 hours, so offset by one half-cycle. Waves of expression are not associated with cell movement and do not require cell contact for propagation, so appear to reflect a cell-autonomous clock that is synchronous in all PSM cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:16:57