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Titolo:
THE B-CELL TRANSMEMBRANE PROTEIN CD72 BINDS TO AND IS AN IN-VIVO SUBSTRATE OF THE PROTEIN-TYROSINE-PHOSPHATASE SHP-1
Autore:
WU YJ; NADLER MJS; BRENNAN LA; GISH GD; TIMMS JF; FUSAKI N; JONGSTRABILEN J; TADA N; PAWSON T; WITHER J; NEEL BG; HOZUMI N;
Indirizzi:
BETH ISRAEL DEACONESS MED CTR,CANC BIOL PROGRAM,DIV HEMATOL ONCOL,DEPT MED BOSTON MA 02215 BETH ISRAEL DEACONESS MED CTR,CANC BIOL PROGRAM,DIV HEMATOL ONCOL,DEPT MED BOSTON MA 02215 MT SINAI HOSP,PROGRAM MOL BIOL & CANC,SAMUEL LUNENFELD RES INST TORONTO ON M5G 1X5 CANADA UNIV TORONTO,DEPT IMMUNOL TORONTO ON M5G 1X5 CANADA TORONTO HOSP,RES INST TORONTO ON M5T 2S8 CANADA SCI UNIV TOKYO,RES INST BIOL SCI NODA CHIBA 278 JAPAN TOKAI UNIV,SCH MED,DEPT PATHOL ISEHARA KANAGAWA 25911 JAPAN UNIV TORONTO,DEPT MOL & MED GENET TORONTO ON M5G 1X5 CANADA UNIV TORONTO,DEPT MED TORONTO ON M5G 1X5 CANADA
Titolo Testata:
Current biology
fascicolo: 18, volume: 8, anno: 1998,
pagine: 1009 - 1017
SICI:
0960-9822(1998)8:18<1009:TBTPCB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN RECEPTOR; INHIBITORY RECEPTOR; CD22-DEFICIENT MICE; SIGNAL-TRANSDUCTION; SURFACE-IGM; CD22; ACTIVATION; ASSOCIATION; APOPTOSIS; SHC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Wu et al., "THE B-CELL TRANSMEMBRANE PROTEIN CD72 BINDS TO AND IS AN IN-VIVO SUBSTRATE OF THE PROTEIN-TYROSINE-PHOSPHATASE SHP-1", Current biology, 8(18), 1998, pp. 1009-1017

Abstract

Background: Signals from the B-cell antigen receptor (BCR) help to determine B-cell fate, directing either proliferation, differentiation, or growth arrest/apoptosis. The protein tyrosine phosphatase SHP-1 is known to regulate the strength of BCR signaling. Although the B-cell co-receptor CD22 binds SHP-1, B cells in CD22-deficient mice are much less severely affected than those in SHP-1-deficient mice, suggesting that SHP-1 may also regulate B-cell signaling by affecting other signaling molecules, Moreover, direct substrates of SHP-1 have not been identified in any B-cell signaling pathway, Results: We identified the B-cell transmembrane protein CD72 as a new SHP-1-binding protein and as an in vivo substrate of SHP-1 in B cells. We also defined the binding sites for SHP-1 and the adaptor protein Grb2 on CD72. Tyrosine phosphorylation of CD72 correlated strongly with BCR-induced growth arrest/apoptosis in B-cell lines and in primary B cells, Preligation of CD72 attenuated BCR-induced growth arrest/death signals in immature and matureB cells or B-cell lines, whereas preligation of CD22 enhanced BCR-induced growth arrest/apoptosis, Conclusions: We have identified CD72 as the first clear in vivo substrate of SHP-1 in B cells, Our results suggest that tyrosine-phosphorylated CD72 may transmit signals for BCR-induced apoptosis. By dephosphorylating CD72, SHP-1 may have a positive role in B-cell signaling, These results have potentially important implications for the involvement of CD72 and SHP-1 in B-cell development and autoimmunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 06:52:44