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Titolo:
THE COMPARATIVE AMINO-ACID-SEQUENCES, SUBSTRATE SPECIFICITIES AND GENE OR CDNA NUCLEOTIDE-SEQUENCES OF SOME PROKARYOTE AND EUKARYOTE AMIDINOTRANSFERASES - IMPLICATIONS FOR EVOLUTION
Autore:
BEDEKAR A; ZINK RM; SHERMAN DH; LINE TV; VANPILSUM JF;
Indirizzi:
UNIV MINNESOTA,SCH MED,DEPT BIOCHEM,4-225 MILLARD HALL,435 DELAWARE ST SE MINNEAPOLIS MN 55455 UNIV MINNESOTA,SCH MED,DEPT BIOCHEM MINNEAPOLIS MN 55455 UNIV MINNESOTA,BELL MUSEUM ST PAUL MN 55108 UNIV MINNESOTA,DEPT MICROBIOL ST PAUL MN 55108 UNIV MINNESOTA,BIOL PROC TECHNOL INST,GORTNER LAB 240 ST PAUL MN 55108
Titolo Testata:
Comparative biochemistry and physiology. B. Comparative biochemistry
fascicolo: 4, volume: 119, anno: 1998,
pagine: 677 - 690
SICI:
0305-0491(1998)119:4<677:TCASSA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARGININE-GLYCINE AMIDINOTRANSFERASE; STREPTOMYCES-GRISEUS; GROWTH-HORMONE; ALPHA-AMYLASES; BIOSYNTHESIS; TRANSAMIDINASE; CREATINE;
Keywords:
AMIDINOTRANSFERASES; HOMO SAPIENS; PETROMYZON MARINUS; RATTUS NORVEGICUS; STREPTOMYCES; SUS SCROFA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A. Bedekar et al., "THE COMPARATIVE AMINO-ACID-SEQUENCES, SUBSTRATE SPECIFICITIES AND GENE OR CDNA NUCLEOTIDE-SEQUENCES OF SOME PROKARYOTE AND EUKARYOTE AMIDINOTRANSFERASES - IMPLICATIONS FOR EVOLUTION", Comparative biochemistry and physiology. B. Comparative biochemistry, 119(4), 1998, pp. 677-690

Abstract

The amino acid sequences of the amidinotransferases and the nucleotide sequences of their genes or cDNA from four Streptomyces species (seven genes) and from the kidneys of rat, pig, human and human pancreas were compared. The overall amino acid and nucleotide sequences of the prokaryotes and eukaryotes were very similar and further, three regionswere identified that were highly identical. Evidence is presented that there is virtually zero chance that the overall and high identity regions of the amino acid sequence similarities and the overall nucleotide sequence similarities between Streptomyces and mammals represent random match. Both rat and lamprey amidinotransferases were able to use inosamine phosphate, the amidine group acceptor of Streptomyces. We have concluded that the structure and function of the amidinotransferases and their genes has been highly conserved through evolution from prokaryotes to eukaryotes. The evolution has occurred with: (1) a high degree of retention of nucleotide and amino acid sequences; (2) a high degree of retention of the primitive Streptomyces guanine + cytosine (G+ C) third codon position composition in certain high identity regions of the eukaryote cDNA; (3) a decrease in the specificities for the amidine group accepters; and (4) most of the mutations silent in the regions suggested to code for active sites in the enzymes. (C) 1998 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:47:00