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Titolo:
2-[F-18]FLUORO-A-85380, AN IN-VIVO TRACER FOR THE NICOTINIC ACETYLCHOLINE-RECEPTORS
Autore:
HORTI AG; SCHEFFEL U; KOREN AO; RAVERT HT; MATHEWS WB; MUSACHIO JL; FINLEY PA; LONDON ED; DANNALS RF;
Indirizzi:
JOHNS HOPKINS MED INST,DIV NUCL MED,615 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DIV NUCL MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DIV RADIAT HLTH SCI BALTIMORE MD 21205 NIDA,INTRAMURAL RES PROGRAM,BRAIN IMAGING CTR BALTIMORE MD 21224
Titolo Testata:
Nuclear medicine and biology
fascicolo: 7, volume: 25, anno: 1998,
pagine: 599 - 603
SICI:
0969-8051(1998)25:7<599:2AITFT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BINDING-SITES; CEREBRAL-CORTEX; POISON FROG; BRAIN; EPIBATIDINE; FLUORINE-18-FPH; AFFINITY; LIGAND; PET;
Keywords:
A-85380 DERIVATIVE; NICOTINIC RECEPTOR; ACETYLCHOLINE RECEPTOR; RADIOTRACER; BRAIN DISTRIBUTION; PHARMACOLOGY; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
A.G. Horti et al., "2-[F-18]FLUORO-A-85380, AN IN-VIVO TRACER FOR THE NICOTINIC ACETYLCHOLINE-RECEPTORS", Nuclear medicine and biology, 25(7), 1998, pp. 599-603

Abstract

The in vivo brain regional distribution of 2-[F-18]fluoro-A-85380, a novel tracer for positron emission tomographic (PET) studies, followedthe regional densities of brain nAChRs reported in the literature. Evidence of binding to nAChRs and high specificity of the binding in vivo was demonstrated by inhibition with nAChR selective ligands as well as with unlabeled 2-fluoro-A-85380. A preliminary toxicology study of the 2-fluoro-A-85380 showed a relatively low biological effect. 2-[F-18]Fluoro-A-85380 holds promise as a useful radiotracer for imaging of nAChRs with PET. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:44:05