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Titolo:
GROWTH-INHIBITION OF NEWLY ESTABLISHED HUMAN GLIOMA CELL-LINES BY LEUKEMIA INHIBITORY FACTOR
Autore:
HALFTER H; KREMERSKOTHEN J; WEBER J; HACKERKLOM U; BARNEKOW A; RINGELSTEIN EB; STOGBAUER F;
Indirizzi:
WESTFALISCHE WILHELMS UNIVERSITAT,NEUROL CLIN,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY WESTFALISCHE WILHELMS UNIVERSITAT,ABT EXPT TUMORBIOL D-48129 MUNSTER GERMANY WESTFALISCHE WILHELMS UNIVERSITAT,INST STRAHLENBIOL D-48129 MUNSTER GERMANY WESTFALISCHE WILHELMS UNIVERSITAT,KLIN RADIOTHERAPIE RADIOONKOL D-48129 MUNSTER GERMANY
Titolo Testata:
Journal of neuro-oncology
fascicolo: 1, volume: 39, anno: 1998,
pagine: 1 - 18
SICI:
0167-594X(1998)39:1<1:GONEHG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CILIARY NEUROTROPHIC FACTOR; CENTRAL-NERVOUS-SYSTEM; SRC-GENE-PRODUCT; IL-6 SIGNAL TRANSDUCER; EXPRESS HIGH-LEVELS; MOLECULAR-CLONING; DIFFERENTIAL EXPRESSION; ONCOSTATIN-M; PP60C-SRC; CNTF;
Keywords:
MALIGNANT GLIOMA; CELL CULTURE; CNTF; LIF; RECEPTOR; CELL GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
H. Halfter et al., "GROWTH-INHIBITION OF NEWLY ESTABLISHED HUMAN GLIOMA CELL-LINES BY LEUKEMIA INHIBITORY FACTOR", Journal of neuro-oncology, 39(1), 1998, pp. 1-18

Abstract

We have established three new cell lines deriving from malignant human gliomas. The cell lines were described in terms of both morphology and growth characteristics. Most cells in all three cell lines expressed the neuroepithelial marker protein GFAP. In terms of growth characteristics, the cells showed only slight differences. The cell lines showed no expression of the neural form of the c-src gene, pp60(c-srcN), but did express the ubiquitous form, pp60(c-src). The established glioma cell lines were also examined for expression of members of the neuropoietic cytokine family, CNTF and LIF, and their respective receptor components CNTFR alpha, LIFR beta and gp130. With the exception of CNTFRa both the ligands and their receptor components were expressed in similar amounts in all three cell lines. The presence of ligand and receptor prompted us to study the effects of exogenously supplied factors on the growth of the glioma cell lines. Whereas LIF induced a high c-fos expression, only low c-fos induction was observed upon CNTF treatment. Accordingly, CNTF did not have any noticeable effects on glioma cell growth in culture, while LIF mediated an inhibiting effect on the growth of the three glioma cell lines in culture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 10:20:44