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Titolo:
CRYOABLATION OF LOCALIZED PROSTATE-CANCER - EXPERIENCE IN 48 CASES, PSA AND BIOPSY RESULTS
Autore:
DERAKHSHANI P; NEUBAUER S; BRAUN M; ZUMBE J; HEIDENREICH A; ENGELMANN U;
Indirizzi:
UNIV COLOGNE,KLIN & POLIKLIN UROL,DEPT UROL,JOSEPH STELZMANN STR 9 D-50924 COLOGNE GERMANY
Titolo Testata:
European urology
fascicolo: 3, volume: 34, anno: 1998,
pagine: 181 - 187
SICI:
0302-2838(1998)34:3<181:COLP-E>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUIDED PERCUTANEOUS CRYOABLATION; CRYOSURGICAL ABLATION; HEPATIC CRYOSURGERY; CRYOTHERAPY; TUMORS;
Keywords:
CRYOABLATION; PROSTATE CANCER; MINIMAL INVASIVE THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Derakhshani et al., "CRYOABLATION OF LOCALIZED PROSTATE-CANCER - EXPERIENCE IN 48 CASES, PSA AND BIOPSY RESULTS", European urology, 34(3), 1998, pp. 181-187

Abstract

Objectives: As the first German center to perform perineal cryoablation of localized prostate cancer, we present our experience in a seriesof 48 consecutive patients. Methods: 7 patients staged T-1, 21 with T-2 disease and 20 patients with T-3 tumor were treated. 62.5% of the patients received neoadjuvant hormonal downsizing. Follow-up ranged from 4 to 27 months with a median of 15 +/- 5.7 months. Results: Positivecontrol biopsies after 6 months were obtained in 0% of T-1 tumors, 16.7% of T-2 tumors and 26.7% of T-3 tumors. Prostate-specific antigen persistence above 1 ng/ml was diagnosed in 14.3, 33.3, and 40%, respectively. Complications were acceptable. 22.9% of the patients had prolonged urinary retention, requiring transurethral resection in 5 patients(10.4%) to relieve obstruction. In 5 cases (10.4%) incontinence was found, in 2 of these patients mild urge incontinence declined over time, in 3 cases moderate to severe stress incontinence developed. Two of these patients were pretreated with radiotherapy. No fistulae were noted. Conclusions: Cryoablation of the prostate is not a substitution for radical prostatectomy but enables the surgeon to perform a radical curative procedure in patients unfit for other radical forms of treatment or unwilling to undergo these. Long-term follow-up and prospective studies are necessary to define the clinical significance of this procedure.

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Documento generato il 20/09/20 alle ore 06:57:04