Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
VALIDATION OF THE 3-DIMENSIONAL ACQUISITION MODE IN POSITRON-EMISSION-TOMOGRAPHY FOR THE QUANTITATION OF [F-18] FLUORO-DOPA UPTAKE IN THE HUMAN STRIATA
Autore:
TREBOSSEN R; BENDRIEM B; RIBEIRO MJ; FONTAINE A; FROUIN V; REMY P;
Indirizzi:
CEA,SERV HOSP FREDERIC JOLIOT,4 PL GEN LECLERC F-91406 ORSAY FRANCE
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 9, volume: 18, anno: 1998,
pagine: 951 - 959
SICI:
0271-678X(1998)18:9<951:VOT3AM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN TRANSFER CONSTANTS; TIME UPTAKE DATA; PARKINSONS-DISEASE; GRAPHICAL EVALUATION; RETRACTABLE SEPTA; PET; RECONSTRUCTION; PERFORMANCE;
Keywords:
3-DIMENSIONAL POSITRON EMISSION TOMOGRAPHY SCATTER CORRECTION; [F-18] FLUORO-DOPA; STRIATOOCCIPITAL RATIO; UPTAKE; PARKINSON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
R. Trebossen et al., "VALIDATION OF THE 3-DIMENSIONAL ACQUISITION MODE IN POSITRON-EMISSION-TOMOGRAPHY FOR THE QUANTITATION OF [F-18] FLUORO-DOPA UPTAKE IN THE HUMAN STRIATA", Journal of cerebral blood flow and metabolism, 18(9), 1998, pp. 951-959

Abstract

Three-dimensional (3D) positron emission tomography (PET) is attractive for [F-18]fluoro-DOPA studies, since the sensitivity improvement ismaximal for radioactive sources located in central planes, which is usually the case for the human striata. However, the image quantitationin that mode must be assessed because of the nearly threefold increase in scattered coincidences. We report the results of [F-18]fluoro-DOPA studies performed on six normal volunteers. Each one was scanned in the 3D and two-dimensional (2D) modes on the same tomograph. The quantitation in the 3D and 2D modes was compared for a Patlak graphical analysis with the occipital counts as the input function (Ki) and a striatooccipital ratio analysis. We find that, in 3D PET, a scatter correction is required to preserve the same quantitation as in 2D PET. When the 3D data sets are corrected for scatter, the quantitation of the [F-18]fluoro-DOPA uptake, using the Patlak analysis, is similar in the 2Dand 3D acquisition modes. Conversely, analysis of the striatooccipital ratio leads to higher values in 3D PET because of a better in-plane resolution. Finally, using the 3D mode, the dose injected to the subjects can be reduced by a factor greater than 1.5 without any loss in accuracy compared to the 2D mode.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:16:43