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Titolo:
RISK OF ESOPHAGEAL AND GASTRIC ADENOCARCINOMAS IN RELATION TO USE OF CALCIUM-CHANNEL BLOCKERS, ASTHMA DRUGS, AND OTHER MEDICATIONS THAT PROMOTE GASTROESOPHAGEAL REFLUX
Autore:
VAUGHAN TL; FARROW DC; HANSTEN PD; CHOW WH; GAMMON MD; RISCH HA; STANFORD JL; SCHOENBERG JB; MAYNE ST; ROTTERDAM H; DUBROW R; AHSAN H; WEST AB; BLOT WJ; FRAUMENI JF;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL,MP-474,POB 19024 SEATTLE WA 98109 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL SEATTLE WA 98109 UNIV WASHINGTON,DEPT PHARM SEATTLE WA 98195 NCI,DIV CANC EPIDEMIOL & GENET BETHESDA MD 20892 COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL NEW YORK NY 10032 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT PATHOL NEW HAVEN CT 06510 NEW JERSEY DEPT HLTH & SENIOR SERV,APPL CANC EPIDEMIOL PROGRAM TRENTON NJ 08625 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 10032 INT EPIDEMIOL INST ROCKVILLE MD 20852
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 9, volume: 7, anno: 1998,
pagine: 749 - 756
SICI:
1055-9965(1998)7:9<749:ROEAGA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RISING INCIDENCE; NORMAL ADULTS; CARDIA; DISEASE; THEOPHYLLINE; CANCER; ANTAGONISTS; NIFEDIPINE; ACHALASIA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Vaughan et al., "RISK OF ESOPHAGEAL AND GASTRIC ADENOCARCINOMAS IN RELATION TO USE OF CALCIUM-CHANNEL BLOCKERS, ASTHMA DRUGS, AND OTHER MEDICATIONS THAT PROMOTE GASTROESOPHAGEAL REFLUX", Cancer epidemiology, biomarkers & prevention, 7(9), 1998, pp. 749-756

Abstract

Incidence of adenocarcinomas of the esophagus and gastric cardia has risen dramatically over the past 2 decades in the U.S., for reasons that are not yet clear. A number of common medications (e.g., calcium channel blockers, tricyclic antidepressants, and certain asthma medications) promote gastroesophageal reflux by relaxing the lower esophageal sphincter (LES), Reflux is thought to increase cancer risk by promoting cellular proliferation, and by exposing the esophageal epithelium topotentially genotoxic gastric and intestinal contents, Recent studieshave suggested that calcium channel blockers may also increase cancerrisk by inhibiting apoptosis, Using personal interview data from a multicenter, population-based case-control study conducted between 1993 and 1995 in three areas of the U.S., we evaluated whether the use of LES-relaxing drugs was associated with increased risk of adenocarcinomas of the esophagus and gastric cardia, Cases of esophageal adenocarcinoma (n = 293) and gastric cardia adenocarcinoma (II = 261) were compared with general population controls (n = 695). Information on additional case groups of esophageal squamous cell carcinoma (II = 221) and noncardia gastric cancer (n = 368) were also available for comparison. Overall, 27.4% of controls had used one or more of these drugs for at least 6 months, compared with 30.2% of esophageal adenocarcinoma and 23.8% of gastric cardia adenocarcinoma cases. The adjusted odds ratios (ORs) for ever use were 1.0 [95% confidence interval (CI) = 0.7-1.5] and 0.8 (95% CI = 0.5-1.1), respectively. There was little evidence of increasing risk with increasing duration of use of all LES-relaxing drugs together, We found an increased risk of esophageal adenocarcinoma among persons reporting use of asthma drugs containing theophylline (OR= 2.5; 95% CI = 1.1-5.6) or beta agonists (OR = 1.7; 95% CI = 0.8-3.8). Risks were higher among long-term users (>5 Sears) of these drugs (OR = 3.1; 95% CI = 0.9-10.3 and OR = 2.3; 95% CI = 0.8-7.0, respectively), In contrast, there was no evidence that the use of calcium channel blockers or other specific groups of drugs increased the risk of anyof the cancers studied, These results provide reassuring evidence that the increases in incidence of adenocarcinomas of the esophagus and gastric cardia are not likely to be related to the use of LES-relaxing drugs as a group, or calcium channel blockers in particular, but they do suggest that persons treated for long-standing asthma may be at increased risk of esophageal adenocarcinoma.

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Documento generato il 18/09/20 alle ore 19:51:57