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Titolo:
EXPRESSION OF CHEMOKINE RECEPTORS CXCR4 AND CCR5 IN HIV-1-INFECTED AND UNINFECTED INDIVIDUALS
Autore:
OSTROWSKI MA; JUSTEMENT SJ; CATANZARO A; HALLAHAN CA; EHLER LA; MIZELL SB; KUMAR PN; MICAN JA; CHUN TW; FAUCI AS;
Indirizzi:
NIAID,IMMUNOREGULAT LAB,NIH,BLDG 10,RM 6A11,10 CTR DR,MSC-1576 BETHESDA MD 20892 GEORGETOWN UNIV,DIV INFECT DIS WASHINGTON DC 20057
Titolo Testata:
The Journal of immunology (1950)
fascicolo: 6, volume: 161, anno: 1998,
pagine: 3195 - 3201
SICI:
0022-1767(1998)161:6<3195:EOCRCA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL ACTIVATION; HIV-1 INFECTION; DISEASE PROGRESSION; FUSION COFACTOR; VIRAL PHENOTYPE; TROPIC HIV-1; RESISTANCE; LYMPHOCYTES; REPLICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Ostrowski et al., "EXPRESSION OF CHEMOKINE RECEPTORS CXCR4 AND CCR5 IN HIV-1-INFECTED AND UNINFECTED INDIVIDUALS", The Journal of immunology (1950), 161(6), 1998, pp. 3195-3201

Abstract

The chemokine receptors CXCR4 and CCR5 have been identified as major coreceptors for HIV-1 entry into CD4(+) T cells. The majority of primary HIV-1 isolates in early disease use CCR5 as a coreceptor, whereas during disease progression with the emergence pf syncytium-inducing viruses, CXCR4 is also used. We performed a cross-sectional study in which we evaluated the expression of two HIV-1 coreceptors, CCR5 and CXCR4, in whole blood samples taken from HIV-1-infected and uninfected individuals. We demonstrate that CXCR4 on CD4(+) and CD8(+) T cells, and CD14(+) monocytes is significantly down-regulated, and CCR5 expression on CD4(+) T cells is up-regulated in HIV-infected individuals comparedwith uninfected controls. Coreceptor expression correlated with the level of cellular activation in vivo in both HIV-infected and uninfected individuals, with CXCR4 being expressed predominantly on quiescent (HLA-DR-) T cells and CCR5 being expressed predominantly on activated (HLA-DR+) T cells, Lower expression of CXCR4 and higher expression of CCR5 on CD4(+) T cells correlated with advancing disease. In addition, a tendency for greater activation of CXCR4(+)CD4(+) T cells in patients with advanced disease was observed. Patients who harbored syncytium-inducing viruses, however, could not be distinguished from those who harbored nonsyncytium-inducing viruses based on the level of CD4(+) T cell activation or chemokine receptor expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:27:08