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Titolo:
MYOCARDIAL-INFARCTION AND USE OF LOW-DOSE ORAL-CONTRACEPTIVES - A POOLED ANALYSIS OF 2 US STUDIES
Autore:
SIDNEY S; SISCOVICK DS; PETITTI DB; SCHWARTZ SM; QUESENBERRY CP; PSATY BM; RAGHUNATHAN TE; KELAGHAN J; KOEPSELL TD;
Indirizzi:
KAISER PERMANENTE MED CARE PROGRAM,DIV RES,3505 BROADWAY OAKLAND CA 94611 UNIV WASHINGTON,CARDIOVASC HLTH RES UNIT SEATTLE WA 98195 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT MED,DIV GEN INTERNAL MED SEATTLE WA 98195 UNIV WASHINGTON,SCH PUBL HLTH & COMMUNITY MED,DEPT BIOSTAT SEATTLE WA98195 KAISER PERMANENTE MED CARE PROGRAM,RES & EVALUAT PASADENA CA 00000 NICHHD,CONTRACEPT & REPROD EVALUAT BRANCH BETHESDA MD 20892
Titolo Testata:
Circulation
fascicolo: 11, volume: 98, anno: 1998,
pagine: 1058 - 1063
SICI:
0009-7322(1998)98:11<1058:MAUOLO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR-DISEASE; INCREASED RISK; WOMEN;
Keywords:
WOMEN; MYOCARDIAL INFARCTION; EPIDEMIOLOGY; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S. Sidney et al., "MYOCARDIAL-INFARCTION AND USE OF LOW-DOSE ORAL-CONTRACEPTIVES - A POOLED ANALYSIS OF 2 US STUDIES", Circulation, 98(11), 1998, pp. 1058-1063

Abstract

Background-Population-based case-control studies to assess the relationship of low-dose oral contraceptive (OC) use with myocardial infarction (MI) were performed at 2 sites in the United States (California and Washington state). The purpose of the present study was to estimate risk of MI in relation to use of low-dose OCs in a pooled analysis combining results from the 2 sites. Methods and Results-The study included as cases women aged 18 to 44 years with incident MI who had no priorhistory of ischemic heart disease or cerebrovascular disease. Women in the case and control groups were interviewed in person regarding OC use and cardiovascular risk factors. The analysis included 271 MI cases and 993 controls. Compared with noncurrent users, the adjusted pooled odds ratio for MI in current OC users was 0.94 (95% CI, 0.44, 2.20) after adjustment for major risk factors and sociodemographic factors. Compared with never users, the adjusted pooled odds ratio for MI was 0.56 (0.21, 1.49) in current OC users and 0.54 (0.31, 0.95) in past OC users. Among past OC users, duration and recency of use were unrelatedto MI risk as was current hormone replacement therapy. There was no evidence of interaction between OC use and age, presence of cardiovascular risk factors (hypercholesterolemia, hypertension, diabetes), obesity, or smoking. Conclusions-We conclude that low-dose OCs as used in these populations are safe with respect to risk of MI in women.

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Documento generato il 27/11/20 alle ore 02:17:45