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Titolo:
KINETICS OF BRADYKININ LEVELS DURING AND AFTER LEUKOCYTE FILTRATION OF PLATELET CONCENTRATES
Autore:
HILD M; SODERSTROM T; EGBERG N; LUNDAHL J;
Indirizzi:
KAROLINSKA HOSP,DEPT CLIN IMMUNOL & TRANSFUS MED S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT CLIN IMMUNOL & TRANSFUS MED S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT CLIN CHEM S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Vox sanguinis
fascicolo: 1, volume: 75, anno: 1998,
pagine: 18 - 25
SICI:
0042-9007(1998)75:1<18:KOBLDA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-REDUCTION FILTER; FEBRILE TRANSFUSION REACTIONS; ANAPHYLACTOID REACTIONS; LDL APHERESIS; HEMODIALYSIS; CD11B/CD18; COMPLEMENT; MEMBRANES; MONOCYTES; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
M. Hild et al., "KINETICS OF BRADYKININ LEVELS DURING AND AFTER LEUKOCYTE FILTRATION OF PLATELET CONCENTRATES", Vox sanguinis, 75(1), 1998, pp. 18-25

Abstract

Objective: To measure beadykinin levels in platelet concentrates during and after leucocyte filtration. Methods: Platelet concentrates wereleukocyte depleted using three different leucocyte-depletion filters selected to represent filters with negative, positive or neutral charge, respectively. Bradykinin levels were analysed before, during and upto 90 min post-filtration. Results: Significant levels of bradykinin were generated when negatively charged leucocyte depletion filters were used. However, we found a high variation between platelet concentrates prepared from different donors as well as within the same concentrate when this was divided into three aliquots. Generated bradykinin wasrapidly degraded in the collection bag and no bradykinin was detectable 60 min post-filtration. Conclusion: Bradykinin generation is more pronounced when negatively charged leucocyte removal filters are used. Due to a rapid degradation of bradykinin in the storage bag, pre-storage filtration should minimise the risk of bradykinin related adverse reactions during transfusion with some filters.

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Documento generato il 17/01/21 alle ore 17:49:40