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Titolo:
DONOR-SPECIFIC STIMULATION OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROMRECIPIENTS OF ORTHOTOPIC LIVER-TRANSPLANTS IS ASSOCIATED, IN THE ABSENCE OF REJECTION, WITH TYPE-2 CYTOKINE PRODUCTION
Autore:
CHUNG SW; YOSHIDA EM; CATTRAL MS; HU YX; GORCZYNSKI RM;
Indirizzi:
VANCOUVER HOSP & HLTH SCI CTR,DEPT SURG,910 W 10TH AVE VANCOUVER BC V5Z 4E3 CANADA VANCOUVER HOSP & HLTH SCI CTR,DEPT MED VANCOUVER BC V5Z 4E3 CANADA UNIV BRITISH COLUMBIA VANCOUVER BC V5Z 1M9 CANADA UNIV TORONTO TORONTO ON CANADA
Titolo Testata:
Immunology letters
fascicolo: 2, volume: 63, anno: 1998,
pagine: 91 - 96
SICI:
0165-2478(1998)63:2<91:DSOPMF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL VENOUS IMMUNIZATION; ANTIGEN-PRESENTING CELLS; ALLOGRAFT-REJECTION; MESSENGER-RNA; HYPORESPONSIVENESS; IMMUNOSUPPRESSION; EXPRESSION; INDUCTION; ADULT; RATS;
Keywords:
MONONUCLEAR CELLS; ORTHOTOPIC LIVER TRANSPLANT; TYPE-2 CYTOKINE PRODUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S.W. Chung et al., "DONOR-SPECIFIC STIMULATION OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS FROMRECIPIENTS OF ORTHOTOPIC LIVER-TRANSPLANTS IS ASSOCIATED, IN THE ABSENCE OF REJECTION, WITH TYPE-2 CYTOKINE PRODUCTION", Immunology letters, 63(2), 1998, pp. 91-96

Abstract

In this study, we examined the cytokine production by human peripheral blood mononuclear cells (PBM) from recipients of orthotopic liver transplants which had been stimulated by donor-specific alloantigen. Levels of interleukin (IL)-2, IL-4, interferon (IFN)-gamma, IL-IO and transforming growth factor (TGF)-beta produced in vitro from PBM of 15 transplant recipients at 5-7 months post transplantation were analysed after donor-specific, third-party, or non-specific stimulation. Mononuclear cell proliferation in response to stimulation and cytokine mRNA from the cell cultures were assayed. Donor-specific antigen was obtained from donor spleen cells which had been obtained and frozen in liquidnitrogen at the time of organ retrieval. Third-party restimulation used equivalent numbers of spleen cells pooled from the other 14 organ donors. Cytokine production was correlated with the clinical condition of the patient, including biopsy results when available, and biochemical data. The data show a highly significant correlation between the donor-specific- and third-party- stimulated IL-4 and IL-10 production from recipient PBM with stable liver graft function as assessed by histopathology and/or biochemistry. This correlation was independent of level of immunosuppression. These data strongly support a role for IL-4 and/or IL-IO in the induction and/or maintenance of tolerance to human liver allografts. Measurement of the levels of these cytokines from recipient PBM after donor-specific antigen stimulation in vitro may be auseful test for monitoring for acute allograft rejection. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 12/07/20 alle ore 03:26:19