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Titolo:
TRAFFICKING PATHWAY OF GLUT4 GLUCOSE TRANSPORTERS IN MUSCLE (REVIEW)
Autore:
ZORZANO A; SEVILLA L; TOMAS E; CAMPS M; GUMA A; PALACIN M;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & BIOL MOL,AV DIAGONAL 645 E-08028 BARCELONA SPAIN
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 3, volume: 2, anno: 1998,
pagine: 263 - 271
SICI:
1107-3756(1998)2:3<263:TPOGGT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SKELETAL-MUSCLE; BROWN ADIPOSE-TISSUE; REGULATED MEMBRANE AMINOPEPTIDASE; INSULIN-STIMULATED TRANSLOCATION; PLASMA-MEMBRANE; CELL-SURFACE; 3T3-L1 ADIPOCYTES; TRANSFERRIN RECEPTOR; CARDIAC MYOCYTES; SNAP RECEPTORS;
Keywords:
GLUCOSE TRANSPORTERS; SKELETAL MUSCLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
A. Zorzano et al., "TRAFFICKING PATHWAY OF GLUT4 GLUCOSE TRANSPORTERS IN MUSCLE (REVIEW)", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2(3), 1998, pp. 263-271

Abstract

Skeletal muscle is a major glucose-utilizing tissue in the absorptivestate and alterations in muscle insulin-stimulated glucose uptake lead to derangements in whole body glucose disposal. The major glucose transporter expressed in skeletal muscle is the GLUT4 isoform. In the muscle fiber, GLUT4 undergoes insulin-stimulated translocation to T-tubules and to sarcolemma and it represents a pharmacological target for the treatment of diabetes mellitus, insulin-resistant states or in cardiac dysfunction. We review recent studies describing the characterization of the cellular steps followed by GLUT4 in muscle and we propose several working models for an integrated structure of the GLUT4 trafficking pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:17:30