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Titolo:
INCREASED SERUM INTERLEUKIN-8 - CORRELATION WITH POOR-PROGNOSIS IN PATIENTS WITH POSTOPERATIVE MULTIPLE ORGAN FAILURE
Autore:
HAMANO K; GOHRA H; NODA H; KATOH T; FUJIMURA Y; ZEMPO N; ESATO K;
Indirizzi:
YAMAGUCHI UNIV,SCH MED,DEPT SURG 1,1144 KOGUSHI UBE YAMAGUCHI 755 JAPAN
Titolo Testata:
World journal of surgery
fascicolo: 10, volume: 22, anno: 1998,
pagine: 1077 - 1081
SICI:
0364-2313(1998)22:10<1077:ISI-CW>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; TUMOR NECROSIS FACTOR; RESPIRATORY-DISTRESS-SYNDROME; SEPTIC SHOCK; CYTOKINE LEVELS; SURGERY; SEPSIS; TRAUMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
K. Hamano et al., "INCREASED SERUM INTERLEUKIN-8 - CORRELATION WITH POOR-PROGNOSIS IN PATIENTS WITH POSTOPERATIVE MULTIPLE ORGAN FAILURE", World journal of surgery, 22(10), 1998, pp. 1077-1081

Abstract

This study investigated whether cytokines and colony-stimulating factors can predict prognosis in patients with postoperative multiple organ failure (MOF). We evaluated 14 patients with postoperative MOF who underwent operation for cardiovascular disease. Seven patients recovered from MOF (survivors) and seven did not recover and died (nonsurvivors). The white blood cell (WBC) count, granulocyte colony-stimulating factor, monocytic colony-stimulating factor, interleukin-6 (IL-6), and IL-8 were measured on the day the patients were judged to be in MOF and each week thereafter until the patients recovered or died. Survivorsand nonsurvivors were equivalent in terms of age, gender, proportion of use of extracorporeal circulation, operation time, volume of blood transfusion, time from operation to the onset of MOF, the MOP score, proportion of bacteremia, duration of MOF, and number of failed organs. The mean duration of MOP was less than 2 weeks in both groups; therefore the measurements were compared on the first day of MOF and 1 week later. No significant differences between the two groups in terms of WBC counts, colony-stimulating factors, and IL-6 levels,were noted. However, the serum level of IL-8 was significantly higher in nonsurvivorsthan in survivors. Patients with a high serum levels of IL-8 at the time of MOF had a poor prognosis.

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Documento generato il 01/12/20 alle ore 01:02:54