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Titolo:
SYNTHESIS OF DINITROXYL CIS-DIAMINOPLATINUM(II) COMPLEXES AND THEIR INTERACTION WITH DNA
Autore:
SEN VD; KULIKOV AV; SHUGALII AV; KONOVALOVA NP;
Indirizzi:
RUSSIAN ACAD SCI,INST CHEM PHYS CHERNOGOLOVKA CHERNOGOLOVKA 142432 MOSCOW REGION RUSSIA
Titolo Testata:
Russian chemical bulletin
fascicolo: 8, volume: 47, anno: 1998,
pagine: 1598 - 1602
SICI:
1066-5285(1998)47:8<1598:SODCCA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
DERIVATIVES; CISPLATIN; BINDING;
Keywords:
PLATINUM(II) COMPLEXES; NITROXYL RADICALS; DNA; PLATINATION; CIS-DIAMMINE-DICHLOROPLATINUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
V.D. Sen et al., "SYNTHESIS OF DINITROXYL CIS-DIAMINOPLATINUM(II) COMPLEXES AND THEIR INTERACTION WITH DNA", Russian chemical bulletin, 47(8), 1998, pp. 1598-1602

Abstract

Dinitroxyl complexes of platinum, cis-Pt-II(APO)(2)X-2, where APO is 4-amino-2,2,6,6-tetramethylpiperidine- 1-oxyl, were obtained by eithera direct reaction of APO with K2PtX4 (X = Cl or I) or a replacement of iodide ligands in cis-Pt-II(APO)(2)I-2 by nitrate and oxalate ligands. The interaction of water-soluble cis-Pt-II(APO)(2)(NO3)(2) with ox spleen DNA resulted in platinated DNA with a degree of modification (r) similar to 7 times lower than that obtained with cis-Pt-II(NH3)(2)Cl-2 (cisplatin). Melting point T-m, melting range Delta T, and the degree of hyperchromicity Delta H for platinated DNA showed that for equalr values, the cis-Pt-II(APO)(2)-DNA adducts increase heterogeneity inthe DNA structure much more effectively than the cis-Pt-II(NH3)(2)-DNA adducts. Poor platinating activity, substantial disturbance of the DNA structure, as well as low toxicity and moderate antitumor activity of cis-Pt-II(APO)(2)X-2 complexes are probably explained by steric hindrances caused by two bulky APO ligands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:34:49