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Titolo:
TENIDAP ENHANCES P2Z P2X(7) RECEPTOR SIGNALING IN MACROPHAGES/
Autore:
SANZ JM; CHIOZZI P; DIVIRGILIO F;
Indirizzi:
UNIV FERRARA,DEPT EXPT & DIAGNOST MED,SECT GEN PATHOL,VIA BORSARI 46 I-44100 FERRARA ITALY UNIV FERRARA,DEPT EXPT & DIAGNOST MED,SECT GEN PATHOL I-44100 FERRARAITALY UNIV FERRARA,CTR BIOTECHNOL I-44100 FERRARA ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 355, anno: 1998,
pagine: 235 - 244
SICI:
0014-2999(1998)355:2-3<235:TEPPRS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACELLULAR ATP; P-2Z RECEPTOR; ION CHANNELS; CELL-DEATH; PURINOCEPTORS; INHIBITION; MONOCYTES; FAMILIES; CULTURES; RELEASE;
Keywords:
TENIDAP; ATP; P2Z/P2X(7) PURINOCEPTOR; MACROPHAGE; INFLAMMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Sanz et al., "TENIDAP ENHANCES P2Z P2X(7) RECEPTOR SIGNALING IN MACROPHAGES/", European journal of pharmacology, 355(2-3), 1998, pp. 235-244

Abstract

Tenidap is an anti-inflammatory drug whose mechanism of action is notfully understood. It has been shown to block plasma membrane anion transport and to decrease release of interleukin-1 beta, probably via the inhibition of interleukin-1 beta converting enzyme. In the present study we showed that: (a) tenidap increases the sensitivity of mouse macrophages to cytotoxic effects mediated by extracellular ATP; (b) tenidap increases lucifer yellow uptake through the macrophage ATP receptor; (c) pretreatment with oxidised ATP, a blocker of the P2Z/P2X(7) receptor, inhibits cytotoxicity and lucifer yellow uptake due to the combined effects of ATP and tenidap; (d) macrophages lacking the P2Z/P2X(7) receptor are resistant to the synergistic effect of tenidap and ATP. The results suggest that tenidap synergises with extracellular ATP for activation of the P2Z/P2X(7) receptor. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:03:30