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Titolo:
SURFACTANT THERAPY RESTORES GAS-EXCHANGE IN LUNG INJURY DUE TO PARAQUAT INTOXICATION IN RATS
Autore:
SO KL; DEBUIJZER E; GOMMERS D; KAISERS U; VANGENDEREN PJJ; LACHMANN B;
Indirizzi:
ERASMUS UNIV,DEPT ANESTHESIOL,ROOM EE 2393,POSTBOX 1738 NL-3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV,DEPT ANESTHESIOL NL-3000 DR ROTTERDAM NETHERLANDS HUMBOLDT UNIV,VIRCHOW CLIN,DEPT ANESTHESIOL & INTENS CARE MED BERLIN GERMANY UNIV HOSP DIJKZIGT,DEPT HEMATOL NL-3015 GD ROTTERDAM NETHERLANDS
Titolo Testata:
The European respiratory journal
fascicolo: 2, volume: 12, anno: 1998,
pagine: 284 - 287
SICI:
0903-1936(1998)12:2<284:STRGIL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXICITY;
Keywords:
ACUTE RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; OXYGEN RADICAL; PARAQUAT; PULMONARY; SURFACTANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
K.L. So et al., "SURFACTANT THERAPY RESTORES GAS-EXCHANGE IN LUNG INJURY DUE TO PARAQUAT INTOXICATION IN RATS", The European respiratory journal, 12(2), 1998, pp. 284-287

Abstract

Paraquat is a weed killer which causes often fatal lung damage in humans and other animals. There is evidence that the pulmonary surfactantsystem is involved in the pathophysiology: of respiratory failure after paraquat intoxication and, therefore, the possible therapeutic effect of intratracheal surfactant administration on gas exchange in rats with progressive lung injury induced by paraquat poisoning was studied. In one group of rats, the time course of the development of lung injury due to paraquat intoxication was characterized. In a second group of rats, 72 h after paraquat intoxication, the animals underwent mechanical ventilation and only those animals in which the arterial oxygen tension/inspiratory oxygen fraction (Pa, O-2/FI, O-2) decreased to below 20 kPa (150 mmHg) received exogenous surfactant (200 mg.kg(-1) bodyweight). Within 3 days the rats in group 1 developed progressive respiratory failure, demonstrated not only by impaired gas exchange and lung mechanics but also by increased minimal surface tension and increased protein concentration in bronchoalveolar lavage fluid, In group 2, intratracheal surfactant administration increased Pa, O-2/FI, O-2 significantly within 5 min (14.4+/-2.4 kPa (108+/-18 mmHg)) to (55.2+/-5.3kPa (414+/-40 mmHg)) and sustained this level for at least 2 h, It isconcluded that intratracheal surfactant administration is a promisingapproach in the treatment of severe respiratory failure caused by paraquat poisoning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:35:08