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Titolo:
CLARITHROMYCIN SIGNIFICANTLY IMPROVES INTERLEUKIN-12-MEDIATED ANTI-MYCOBACTERIUM AVIUM ACTIVITY AND ABOLISHES TOXICITY IN MICE
Autore:
BERMUDEZ LE; PETROFSKY M; WU M; YOUNG LS;
Indirizzi:
CALIF PACIFIC MED CTR,KUZELL INST,INST RES,2200 WEBSTER ST,ROOM 305 SAN FRANCISCO CA 94115
Titolo Testata:
The Journal of infectious diseases
fascicolo: 3, volume: 178, anno: 1998,
pagine: 896 - 899
SICI:
0022-1899(1998)178:3<896:CSIIA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; INFECTION; COMPLEX; CELLS; EXPRESSION; RESISTANCE; GROWTH; GAMMA; ALPHA; IL-12;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "CLARITHROMYCIN SIGNIFICANTLY IMPROVES INTERLEUKIN-12-MEDIATED ANTI-MYCOBACTERIUM AVIUM ACTIVITY AND ABOLISHES TOXICITY IN MICE", The Journal of infectious diseases, 178(3), 1998, pp. 896-899

Abstract

Treatment of experimental murine Mycobacterium avium (MAC) infection with interleukin-12 (IL-12) significantly decreased MAC organisms in tissue but resulted in toxicity, Because IL-12-related toxicity was seen only in infected mice, IL-12 was combined with clarithromycin in an attempt to decrease bacterial burden. Clarithromycin (200 mg/kg/day) was administered alone to M. avium-infected mice for 1 week, and from week 2, IL-12 (20 mu g/kg twice per week) was added to the regimen for 4 weeks. Treatment with IL-12 resulted in 60% mortality, compared with40% mortality in untreated control mice and 20% when IL-12 was given with clarithromycin (P <.05), Clarithromycin plus IL-12 resulted in increased activity compared with either clarithromycin or IL-12 alone inreducing the number of bacteria in spleen and blood. Although potentially toxic, IL-12 is an effective immunotherapy for MAC infection, andcombination with clarithromycin reduces IL-12 toxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:51:41