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Titolo:
ANALYSIS OF EVENTS LEADING TO NEURONAL DEATH AFTER INFECTION WITH E1-DEFICIENT ADENOVIRAL VECTORS
Autore:
EASTON RM; JOHNSON EM; CREEDON DJ;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT MOL BIOL & PHARMACOL ST LOUIS MO 63110
Titolo Testata:
Molecular and cellular neurosciences (Print)
fascicolo: 5-6, volume: 11, anno: 1998,
pagine: 334 - 347
SICI:
1044-7431(1998)11:5-6<334:AOELTN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED GENE-TRANSFER; NERVE GROWTH-FACTOR; PROGRAMMED CELL-DEATH; RAT SYMPATHETIC NEURONS; RECOMBINANT ADENOVIRUSES; IN-VIVO; POSTMITOTIC NEURONS; PROTEIN-SYNTHESIS; CYSTIC-FIBROSIS; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Easton et al., "ANALYSIS OF EVENTS LEADING TO NEURONAL DEATH AFTER INFECTION WITH E1-DEFICIENT ADENOVIRAL VECTORS", Molecular and cellular neurosciences (Print), 11(5-6), 1998, pp. 334-347

Abstract

Although recombinant adenoviral vectors are being widely used to target genes to the nervous system, the cellular and genetic effects of recombinant adenoviral infection on neurones function have not been wellcharacterized, Using sympathetic neuronal cultures, we analyzed the effect of adenoviral infection on viral and neuronal gene expression and on neuronal function and viability. While a delayed cytotoxicity occurred 5 days after infection, numerous biochemical and genetic perturbations occurred within the infected cell prior to this time. This study demonstrates that numerous cellular alterations were produced by recombinant adenoviral vectors and, therefore, emphasizes the need for ananalysis of the effects of these viral vectors on neuronal function in the interpretation of data regarding transgene expression induced bythese vectors in neurons. It also suggests that continued improvements made to the viral vectors themselves might decrease this direct cytotoxicity and lead to improved safety and function of recombinant adenovirus in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:13:57