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Titolo:
STATIC AND DYNAMIC-MECHANICAL PROPERTIES OF THE CAROTID-ARTERY FROM NORMOTENSIVE AND HYPERTENSIVE RATS
Autore:
LICHTENSTEIN O; SAFAR ME; MATHIEU E; POITEVIN P; LEVY BI;
Indirizzi:
INSERM U141,41 BLVD CHAPELLE F-75475 PARIS FRANCE HOP LARIBOISIERE,INSERM U141,IFR CIRCULAT F-75475 PARIS FRANCE HOP LARIBOISIERE,INSERM U337,IFR CIRCULAT F-75475 PARIS FRANCE
Titolo Testata:
Hypertension
fascicolo: 2, volume: 32, anno: 1998,
pagine: 346 - 350
SICI:
0194-911X(1998)32:2<346:SADPOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME; IN-VIVO; DISTENSIBILITY; INHIBITION;
Keywords:
CAROTID ARTERIES; STIFFNESS; VISCOSITY; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
O. Lichtenstein et al., "STATIC AND DYNAMIC-MECHANICAL PROPERTIES OF THE CAROTID-ARTERY FROM NORMOTENSIVE AND HYPERTENSIVE RATS", Hypertension, 32(2), 1998, pp. 346-350

Abstract

Several recent results obtained in hypertensive animals and subjects under in vivo isobaric conditions do not confirm the classic view of stiffer arteries in hypertensive subjects. We compared the mechanical behavior of in situ isolated common carotid arteries from normotensive Wistar-Kyoto rats (WKY) and age-matched spontaneously hypertensive rats (SHR) under both static and dynamic conditions for transmural pressure ranging from 50 to 200 mm Hg, The static pressure (P)-diameter (D) relationship was shifted to higher values of diameters in the SHR mainly because of a larger unstressed carotid diameter (D-o) in hypertensive rats. The carotid mechanical strain, calculated as (D-D-o)/D-o, wassignificantly reduced in SHR at pressure levels between 100 and 200 mm Hg. The static carotid compliance and distensibility were markedly smaller in SHR than in WKY carotid arteries, indicating a stiffer wall in hypertensive animals. In contrast, carotid compliance and distensibility were similar under dynamic conditions close to the in vivo pulsepressure (frequency, 300 bpm; peak amplitude of the oscillatory pressure, 20 to 25 mm Hg). However, marked differences in dynamic compliance- and distensibility-strain relationships in SHR and WKY are evidenceof clearly different arterial wall material properties in bath strains. We therefore conclude that larger lumen carotid arteries in hypertensive rats could compensate for a stiffer arterial wall, resulting in similar dynamic compliance and distensibility in normotensive and hypertensive rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:35:03