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Titolo:
NONAQUEOUS CAPILLARY ELECTROPHORETIC SEPARATION OF ENANTIOMERS USING THE SINGLE-ISOMER HEPTAKIS(2,3-DIACETYL-6-SULFATO)-BETA-CYCLODEXTRIN AS CHIRAL RESOLVING AGENT
Autore:
VINCENT JB; VIGH G;
Indirizzi:
TEXAS A&M UNIV,DEPT CHEM COLLEGE STN TX 77842 TEXAS A&M UNIV,DEPT CHEM COLLEGE STN TX 77842
Titolo Testata:
Journal of chromatography
fascicolo: 2, volume: 816, anno: 1998,
pagine: 233 - 241
Fonte:
ISI
Lingua:
ENG
Soggetto:
DANSYL-AMINO ACIDS; BETA-CYCLODEXTRIN; FAMILY;
Keywords:
ENANTIOMER SEPARATION; BACKGROUND ELECTROLYTE COMPOSITION; CYCLODEXTRINS; CIPROFIBRATE; FENOPROFEN; IBUPROFEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Vincent e G. Vigh, "NONAQUEOUS CAPILLARY ELECTROPHORETIC SEPARATION OF ENANTIOMERS USING THE SINGLE-ISOMER HEPTAKIS(2,3-DIACETYL-6-SULFATO)-BETA-CYCLODEXTRIN AS CHIRAL RESOLVING AGENT", Journal of chromatography, 816(2), 1998, pp. 233-241

Abstract

The sodium salt of the single isomer heptakis(2,3-diacetyI-6-sulfato)-beta-cyclodextrin has been used as chiral resolving agent for the nonaqueous capillary electrophoretic separation of the enantiomers of a variety of weak base pharmaceuticals in 100% methanol background electrolytes. As predicted by the charged resolving agent migration model ofenantiomer separations, very large separation selectivities were observed for the cationic analytes around the heptakis(2,3-diacetyl-6-sulfato)-beta-cyclodextrin concentrations where the effective mobilities of the slower migrating enantiomers approached zero. Neutral analytes and acidic analytes complexed very weakly with heptakis(2,3-diacetyI-6-sulfato)-beta-cyclodextrin in the methanolic background electrolytes. Heptakis(2,3-diacetyl-6-suIfato)-beta-cyclodextrin proved to be a useful chiral resolving agent in 100% methanolic background electrolytes for a variety of weak base analytes that have limited solubilities in aqueous background electrolytes. (C) 1998 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/09/20 alle ore 12:55:49