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Titolo:
CLUES TO THE FUNCTION OF THE TUMOR SUSCEPTIBILITY GENE BRCA2
Autore:
GAYTHER SA; PONDER BAJ;
Indirizzi:
ADDENBROOKES HOSP,CRC,HUMAN CANC GENET RES GRP,BOX 238,HILLS RD CAMBRIDGE CB2 2QQ ENGLAND
Titolo Testata:
Disease markers
fascicolo: 1, volume: 14, anno: 1998,
pagine: 1 - 8
SICI:
0278-0240(1998)14:1<1:CTTFOT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC CELLULAR PROLIFERATION; BREAST-CANCER FAMILIES; MUTATION ANALYSIS; OVARIAN-CANCER; EXPRESSION PATTERN; GERMLINE MUTATIONS; MOUSE; RAD51; MICE; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Gayther e B.A.J. Ponder, "CLUES TO THE FUNCTION OF THE TUMOR SUSCEPTIBILITY GENE BRCA2", Disease markers, 14(1), 1998, pp. 1-8

Abstract

The breast cancer susceptibility gene BRCA2 was isolated in 1995. BRCA2 is a large gene comprising 10,254 nucleotides and 26 coding exons. Neither the nucleotide nor the predicted protein sequences (comprising3,418 amino acids) have provided substantial clues about its function. As a result, researchers have been trying to elucidate the function using a combination of cell biological and biochemical methods and theconstruction of animal models using gene targeting in mice. Recent data suggest that BRCA2 may participate in pathways associated with recombination or double-strand DNA break repair and may act by either sensing or responding to DNA damage. In addition, there is evidence to suggest that BRCA2 functions in a manner similar to the previously isolated breast cancer susceptibility gene BRCA1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:51:25