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Titolo:
CEREBRAL TOXOPLASMOSIS AND LYMPHOMA IN AIDS - PERFUSION MR-IMAGING EXPERIENCE IN 13 PATIENTS
Autore:
ERNST TM; CHANG L; WITT MD; ARONOW HA; CORNFORD ME; WALOT I; GOLDBERG MA;
Indirizzi:
UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT RADIOL,1124 W CARSON ST,N-11 TORRANCE CA 90502 UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT NEUROL TORRANCE CA 90502 UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT MED TORRANCE CA 90502 UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DEPT PATHOL TORRANCE CA 90502 UNIV SO CALIF,SCH MED,DEPT NEUROL LOS ANGELES CA 90033
Titolo Testata:
Radiology
fascicolo: 3, volume: 208, anno: 1998,
pagine: 663 - 669
SICI:
0033-8419(1998)208:3<663:CTALIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM LYMPHOMA; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; IMMUNE-DEFICIENCY-SYNDROME; EPSTEIN-BARR-VIRUS; BRAIN; SPECTROSCOPY; CONTRAST; LESIONS; SPECT; CT;
Keywords:
ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS); BRAIN, MR; BRAIN NEOPLASMS, DIAGNOSIS; LYMPHOMA; LYMPHOMATOID GRANULOMATOSIS; MAGNETIC RESONANCE (MR), PERFUSION STUDY; TOXOPLASMOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Ernst et al., "CEREBRAL TOXOPLASMOSIS AND LYMPHOMA IN AIDS - PERFUSION MR-IMAGING EXPERIENCE IN 13 PATIENTS", Radiology, 208(3), 1998, pp. 663-669

Abstract

PURPOSE: To evaluate the perfusion magnetic resonance (MR) imaging characteristics of cerebral toxoplasmosis and lymphoma in patients with acquired immunodeficiency syndrome (AIDS). MATERIALS AND METHODS: Perfusion MR imaging was performed prospectively in 13 patients with AIDS who had contrast material-enhancing focal brain lesions (six with active lymphoma, five with toxoplasmosis, one with treated lymphoma in remission, and one with toxoplasmosis plus lymphomatoid granulomatosis). Regional cerebral blood volume (rCBV) was determined by using dynamic echo-planar MR imaging during bolus injection of a gadolinium chelate. RESULTS: The rCBV was decreased (44% +/- 24 [standard deviation] of rCBV in contralateral regions) throughout the toxoplasmosis lesions andin the surrounding edema of both lesion types, whereas all active lymphomas displayed areas of increased rCBV (258% +/- 99). These differences were significant (P < .005) CONCLUSION: Reduced rCBV in toxoplasmosis lesions is probably due to a lack of vasculature within the abscess; increased rCBV in lymphomas is probably due to hypervascularity in foci of active tumor growth; and decreased rCBV in the edema is probably due to vasoconstriction associated with increased interstitial pressure. Perfusion MR imaging is a rapid, noninvasive tool that may allowdifferentiation between cerebral lymphoma and toxoplasmosis in patients with AIDS.

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Documento generato il 30/09/20 alle ore 09:43:11